Aim: The aim of this study was to present and analyze detailed clinicopathological data of periapical cysts (PCs) and periapical granuloma (PG) in a cohort of 135 cases from the South Indian Population.
Methodology: The present study included 135 cases of PC and PG out of 2696 biopsies submitted over 3 years. The clinicodemographic data which included age, gender, location, radiographic appearance, and treatment were collected along with the histopathological examination of the biopsied specimen. Data were entered in a Microsoft Excel spreadsheet, 2021, and analyzed using SPSS software ver. 26.
Results: There were 71 cases of PG and 64 cases of PC. The mean age of occurrence in PG was slightly lower than cases in PC. Irrespective of the group, there was a clear male preponderance, and maxillary permanent central incisors were most commonly affected. However, no significant difference was noted. Radiographically, PC significantly showed more well-defined corticated radiolucent lesions compared to PG where most cases were ill-defined (69.01%). Histologically, all cases showed classic features for diagnosis with additional histological characteristics which may aid in diagnosis.
Conclusion: PG was more common than PC. There was a predilection for the male gender in both lesions. The actual incidence of these lesions would be actually high, as some cases are lost to private practitioners, and not all the lesions are submitted for histopathological examination.
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http://dx.doi.org/10.4103/JCDE.JCDE_160_24 | DOI Listing |
Eur J Dent
December 2024
College of Medicine, Research and Graduate Studies, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Objectives: This study aimed to evaluate the expression levels of hypoxia-inducible factor 1-α (HIF-1α) and vascular endothelial growth factor (VEGF) in radicular cysts and periapical granulomas, thereby contributing to the understanding of their potential significance in the differential diagnosis and treatment of these lesions.
Materials And Methods: In the present cross-sectional study, 51 samples of periapical lesions were included. Of them, 24 samples were radicular cysts, and 27 samples were periapical granulomas.
Diagnostics (Basel)
October 2024
Department of Microscopic Morphology/Histology, Angiogenesis Research Center, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Background/objectives: The main mechanism of the formation of granulation tissue is the progression of an infection from the tooth to the periapical bone. At this level, the immune system tries to localize and annihilate the microorganism's injury. Ki-67 is a protein directly associated with the cell proliferation rate, while CD34 is a biomarker involved in angiogenesis, and studies suggest that they both have a positive correlation with the intensity of the local inflammatory infiltrate.
View Article and Find Full Text PDFJ Conserv Dent Endod
September 2024
Department of Dentistry, All India Institute of Medical Sciences, Rajkot, Gujarat, India.
Periapical lesions with mixed radiographic appearance can have odontogenic or nonodontogenic origin. A number of neoplastic lesions either benign or malignant can present as radiolucent, radiopaque, or mixed in jaws and if present near the root apices can be misdiagnosed as odontogenic infection/etiology. The present case report describes a rare case of two elongated radiopaque structures within periapical pathology located beneath the apices of mandibular central incisors in a 26-year-old male.
View Article and Find Full Text PDFJ Oral Biosci
October 2024
Department of Endodontics, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan; Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. Electronic address:
Objectives: This study investigates whether latent Epstein-Barr virus (EBV) can be reactivated by n-butyric acid from Pseudoramibacter alactolyticus, and if such reactivation induces expression of interleukin (IL)-1β and IL-6 in periapical granulomas.
Methods: We analyzed periapical granulomas and healthy gingival tissues to detect the presence of EBV and P. alactolyticus.
Cureus
September 2024
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
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