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Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.
Invest Ophthalmol Vis Sci
January 2025
Laboratory of Anatomy of Domestic Animals, National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing, China.
Purpose: Because chickens have excellent light perception properties, this study focused on investigating whether monochromatic light can cause photodamage in chicken retinal ganglion cells (RGCs).
Methods: Post-hatching day chickens were exposed to four different light-emitting diode light environments for five weeks, respectively, monochromatic blue light (480 nm), green light (560 nm), red light (660 nm), or white light (6000 K). The mechanisms through which monochromatic light influences the structure of the chicken retina were analyzed by detecting the morphological structure of the retina, gene and protein expression levels, and the ultrastructure of the optic nerve.
Complications occur with total shoulder arthroplasty (TSA), and they can be daunting to diagnose and treat. It is important to review common TSA-related complications and to summarize risk factors along with causes of these complications and how to avoid them. The orthopaedic surgeon should be knowledgeable about how to successfully manage complications to achieve good patient outcomes and the etiologies and management of the painful and stiff shoulder arthroplasty, subscapularis failure after anatomic TSA, instability after reverse shoulder arthroplasty, and acromion stress fractures in the setting of reverse TSA.
View Article and Find Full Text PDFMorphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in .
Infect Immun
December 2024
Laboratory of Intracellular Bacterial Pathogens, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.
Type III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold. This spatial arrangement explains why modifications in PG structure can alter T3SS activity. In incorporation of non-canonical D-amino acids in the PG was shown to decrease the activity of the T3SS encoded by the pathogenicity island-1 (SPI-1) without affecting other T3SS, like the flagellum apparatus.
View Article and Find Full Text PDFAcute myocardial infarction (MI) is a leading cause of death worldwide. Although with current treatment, acute mortality from MI is low, the damage and remodeling associated with MI are responsible for subsequent heart failure. Reducing cell death associated with acute MI would decrease the mortality associated with heart failure.
View Article and Find Full Text PDFPromoting Classroom Climate and Why it Matters in Anti-Hate Speech Prevention Programs: A HateLess Evaluation Study.
J Interpers Violence
January 2025
Indiana State University, Terre Haute, USA.
Inclusive and supportive classroom environments are essential, particularly during political and societal crises such as wars, disinformation, polarization, and rising populism and extremism. While existing research underscores the importance of such environments, few studies comprehensively examine the impact of anti-hate speech prevention programs on classroom dynamics and students' social development. This study addressed this gap by investigating the direct and indirect effects of the HateLess anti-hate speech prevention program on inclusive classroom climate, classroom cohesion, empathy, and self-efficacy among adolescents.
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