AI Article Synopsis
- Granuloma annulare is a skin condition that can be difficult to treat, especially in its generalized form, affecting about 15% of patients.
- Two women, aged 60 and 41, had severe cases that didn't respond to standard treatments like steroids and antibiotics.
- Both patients showed significant improvement after taking upadacitinib, with one achieving complete clearance of lesions in 2 months and the other following suit within 4 months, suggesting a potential new treatment option.
Article Abstract
Granuloma annulare is a poorly understood dermatosis that, when generalized, can occur in up to 15 percent of patients. In these cases, treatment is frustrating and experimental. We report a case of a 60-year-old woman and a 41-year-old woman who demonstrated resolution of recalcitrant, generalized granuloma annulare (GA) following oral treatment with upadacitinib. After showing little to no response to other various treatments, such as steroids, antibiotic regimens, and systemic therapies, each patient was started on 15 mg of daily upadacitinib. At 2 months, one patient had complete clearance of all lesions while the other patient experienced noticeable improvement. Within 4 months, the other patient reached total resolution of her lesions. These cases provide evidence of a therapeutic option that may shorten disease duration and provide relief from cutaneous disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208790 | PMC |
| http://dx.doi.org/10.1155/2024/8859178 | DOI Listing |
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