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Introduction: Inflammatory bowel diseases (IBD) are characterised by chronic inflammation of the gastrointestinal tract. There aetiopathogenesis has not yet been fully elucidated. is one of the most abundant in human gut, and it is found in about 5% of the gut microbiota.
Aim: To study the role of in Egyptian patients with ulcerative colitis (UC) and Crohn's disease (CD) and to assess its relationship with the disease activity.
Material And Methods: This study includes 80 patients divided as follows: group I: 30 patients with UC; group II: 30 patients with CD; and group III: 20 healthy patients as control. DNA execration was performed using a faecal extraction kit and quantitative SYBR green real time PCR to identify the core of .
Results: In group 1 of UC patients, the level of bacteria was reduced by a mean of 1.68E-01, and in the control group by a mean of 2.72E-01 ( = 0.004, significant). Regarding in UC patients according to Mayo score, in severe patients the level of bacteria was reduced significantly by a median of 4.80E-02. Regarding in group 2 of CD, the level of bacteria was significantly reduced by mean of 1.70E-01, and in the control group by a mean of 2.72E-01 ( = 0.037, significant).
Conclusions: There was a significant difference between CD and UC patients and the control group in . There was a significant reduction in the level of in severe UC cases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200077 | PMC |
| http://dx.doi.org/10.5114/pg.2024.139427 | DOI Listing |
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