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| http://dx.doi.org/10.3389/fendo.2024.1442803 | DOI Listing |
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Sleep dysfunction in aspirin exacerbated respiratory disease: A prospective cohort study.
World J Otorhinolaryngol Head Neck Surg
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Objective: Studies have described sleep dysfunction (SD) in patients with chronic rhinosinusitis (CRS). However, there is a paucity of literature describing sleep dysfunction in the context of aspirin-exacerbated respiratory disease (AERD). The purpose of this study was to evaluate the prevalence and severity of SD in patients with AERD relative to CRS.
View Article and Find Full Text PDFFerroptosis and cuproptosis in periodontitis: recent biological insights and therapeutic advances.
Front Immunol
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Department of Endodontics, Southern Medical University Stomatological Hospital, Guangzhou, China.
Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research and clinical attention. Although ferroptosis and cuproptosis have emerged as significant areas of research in the medical field, their precise roles in the pathogenesis of periodontitis remain unclear. We aim to systematically summarize the current research on ferroptosis and cuproptosis in periodontal disease and investigate the roles of glutathione pathway and autophagy pathway in connecting ferroptosis and cuproptosis during periodontitis.
View Article and Find Full Text PDFNeutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection.
Front Immunol
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Fundación Española para el Estudio y Terapéutica de la Enfermedad de Gaucher y otras lisosomales (FEETEG), Zaragoza, Spain.
Background: SARS-CoV-2 infection activates macrophages and induces the release of neutrophil extracellular traps (NETs). Excess NETs is linked to inflammatory and thrombotic complications observed in COVID-19.
Aim: To explore the impact of NETs and macrophage activation on SARS-CoV-2-infected patients who developed complications.
The tumor coagulome as a potential biological determinant of postsurgical recurrence of oral squamous cell carcinoma.
Front Oral Health
February 2025
UR7516 CHIMERE, Université de Picardie Jules Verne, Amiens, France.
Objectives: The tumor coagulome is an intrinsic characteristic of human tumors and a key determinant of cancer-associated thrombosis (CAT). Oral Squamous Cell Carcinoma (OSCC) establish a local procoagulant state that contributes to a broad range of vascular complications, and potentially also to tumor progression. Recent clinical studies suggest that biomarkers of coagulation might be of interest for predicting postsurgical recurrence of OSCC, but it remains unclear whether specific properties of the coagulome of OSCC are conducive to postsurgical recurrence.
View Article and Find Full Text PDFSalt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage.
Stem Cell Reports
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Institute of Translational Stem Cell Research, Helmholtz Diabetes Center, Helmholtz Zentrum Munchen, Munich, Germany; Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark. Electronic address:
The extracellular matrix-F-actin-Yes-associated protein 1 (YAP1)-Notch mechanosignaling axis is a gatekeeper in the fate decisions of bipotent pancreatic progenitors (bi-PPs). However, the link between F-actin dynamics and YAP1 activity remains poorly understood. Here, we identify salt-inducible kinases (SIKs) as mediators of F-actin-triggered changes in YAP1 activity.
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