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| http://dx.doi.org/10.1016/j.jacadv.2023.100263 | DOI Listing |
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Prognostic and therapeutic implications of low aortic valve calcium score in patients with low gradient aortic stenosis.
Eur Heart J Cardiovasc Imaging
October 2024
Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.
Introduction: Low gradient (LG) aortic stenosis (AS) poses a diagnostic challenge. Aortic valve calcium score (AVCS) assessment has emerged as a complementary diagnostic method when echocardiography provides discordant results. However, the diagnostic and prognostic value of AVCS in LGAS has not been thoroughly studied.
View Article and Find Full Text PDFHigh-Gradient Aortic Stenosis With Valve Area >1.0 cm: The "Forgotten" Discordant Hemodynamic Phenotype.
JACC Cardiovasc Imaging
September 2024
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:
Article Synopsis
- This study focuses on patients with high-gradient aortic stenosis (AS) who have an aortic valve area greater than 1.0 cm, analyzing their clinical features and outcomes.
- It found that this group was younger, mostly male, had fewer health issues, and a higher prevalence of a bicuspid valve compared to other AS patients.
- The results indicated that while these patients had a better overall prognosis, those who underwent aortic valve replacement experienced even better survival rates, emphasizing the benefits of timely treatment.
A novel functional index, aortic-valve-coefficient, for assessing aortic-stenosis in patients undergoing TAVR: A prospective-pilot study.
Cardiovasc Revasc Med
August 2024
Department of Biomedical Engineering, University of Cincinnati, Veterans Affairs Medical Center, Cincinnati, OH, USA. Electronic address:
Background: Evaluating the severity of aortic stenosis (AS) can be challenging, particularly in patients with low-gradient (LG, Δp < 40 mmHg) AS.
Objective: This study aims to improve the accuracy of assessing severity of AS using a novel functional index- Aortic Valve Coefficient (AVC). The AVC is defined as ratio of mean transvalvular pressure-drop (Δp) to the proximal dynamic pressure (1/2 × blood density × V; V: left ventricular outflow tract peak velocity).
Transcatheter Aortic Valve Replacement Across Hemodynamic Subtypes of Severe Aortic Valve Stenosis: A Network Meta-analysis.
J Soc Cardiovasc Angiogr Interv
March 2024
Department of Cardiology, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania.
Background: Studies assessing outcomes of transcatheter aortic valve replacement (TAVR) in patients with severe aortic valve stenosis (AS) with hemodynamic subtypes have demonstrated mixed results with respect to outcomes and periprocedural complications. This study aimed to assess the outcomes of TAVR in patients across various hemodynamic subtypes of severe AS.
Methods: PubMed, Embase, and Cochrane databases were searched through September 2023 to identify all observational studies comparing outcomes of TAVR in patients with paradoxical low flow low gradient (pLFLG), classic LFLG, and high gradient AS (HGAS).
Impact of Stress Echocardiography on Aortic Valve Stenosis Management.
J Clin Med
June 2024
First Department of Cardiology, National and Kapodistrian University of Athens, Hippokration General Hospital of Athens, 11527 Athens, Greece.
Rest and stress echocardiography (SE) play a fundamental role in the evaluation of aortic valve stenosis (AS). According to the current guidelines for the echocardiographic evaluation of patients with aortic stenosis, four broad categories can be defined: high-gradient AS (mean gradient ≥ 40 mmHg, peak velocity ≥ 4 m/s, aortic valve area (AVA) ≤ 1 cm or indexed AVA ≤ 0.6 cm/m); low-flow, low-gradient AS with reduced ejection fraction (mean gradient < 40 mmHg, AVA ≤ 1 cm, left ventricle ejection fraction (LVEF) < 50%, stroke volume index (Svi) ≤ 35 mL/m); low-flow, low-gradient AS with preserved ejection fraction (mean gradient < 40 mmHg, AVA ≤ 1 cm, LVEF ≥ 50%, SVi ≤ 35 mL/m); and normal-flow, low-gradient AS with preserved ejection fraction (mean gradient < 40 mmHg, AVA ≤ 1 cm, indexed AVA ≤ 0.
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