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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198159 | PMC |
| http://dx.doi.org/10.1016/j.jacadv.2023.100355 | DOI Listing |
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Cardiac tissue model of immune-induced dysfunction reveals the role of free mitochondrial DNA and the therapeutic effects of exosomes.
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March 2024
Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Article Synopsis
- Researchers created a heart-on-a-chip model that includes immune cells to study the effects of SARS-CoV-2 on heart inflammation.
- This model demonstrated that infection leads to increased inflammation, impaired heart function, and elevated levels of mitochondrial damage markers.
- The study found that using exosomes from endothelial cells could reverse heart function issues, regulate calcium levels, lower inflammatory markers, and decrease mitochondrial damage.
Heart-on-a-chip systems: disease modeling and drug screening applications.
Lab Chip
February 2024
Microsystems and Nanotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Cardiovascular disease (CVD) is the leading cause of death worldwide, casting a substantial economic footprint and burdening the global healthcare system. Historically, pre-clinical CVD modeling and therapeutic screening have been performed using animal models. Unfortunately, animal models oftentimes fail to adequately mimic human physiology, leading to a poor translation of therapeutics from pre-clinical trials to consumers.
View Article and Find Full Text PDFCardiovascular disease continues to take more human lives than all cancer combined, prompting the need for improved research models and treatment options. Despite a significant progress in development of mature heart-on-a-chip models of fibrosis and cardiomyopathies starting from induced pluripotent stem cells (iPSCs), human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip system with circulating immune cells to model SARS-CoV-2-induced acute myocarditis.
View Article and Find Full Text PDFHeart-on-a-Chip: Leveraging Technology for Sickle Cell Disease.
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Division of Cardiac Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Modeling Heart Diseases on a Chip: Advantages and Future Opportunities.
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February 2023
Toronto General Hospital Research Institute (O.M., R.Y., M.L., S.S.N.), University Health Network, Toronto, Canada.
Heart disease is a significant burden on global health care systems and is a leading cause of death each year. To improve our understanding of heart disease, high quality disease models are needed. These will facilitate the discovery and development of new treatments for heart disease.
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