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A chemically modified DNAzyme-based electrochemical sensor for binary and highly sensitive detection of reactive oxygen species.
Chem Sci
January 2025
School of Chemistry and Materials Science, Jiangsu Normal University Xuzhou 221116 China
Reactive oxygen species (ROS) play a critical role in regulating various physiological processes. To gain a comprehensive understanding of their distinct functions in different physiological events, it is imperative to detect binary ROS simultaneously. However, the development of the sensing method capable of binary ROS detection remains a significant challenge.
View Article and Find Full Text PDFA bibliometric and visualization analysis of electrochemical biosensors for early diagnosis of eye diseases.
Front Med (Lausanne)
January 2025
Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Electrochemical biosensors can provide an economical, accurate and rapid method for early screening of disease biomarkers in clinical medicine due to their high sensitivity, selectivity, portability, low cost and easy manufacturing, and multiplexing capability. Tear, a fluid naturally secreted by the human body, is not only easily accessible but also contains a great deal of biological information. However, no bibliometric studies focus on applying electrochemical sensors in tear/eye diseases.
View Article and Find Full Text PDFAdvancing healthcare through laboratory on a chip technology: Transforming microorganism identification and diagnostics.
World J Clin Cases
January 2025
Department of Basic Sciences, Biomedical Stomatology Research Group, Universidad de Antioquia U de A, Medellín 0057, Colombia.
In a recent case report in the , emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment outcomes. Laboratory-on-a-chip (LOC) technology has emerged as a transformative tool in health care, offering rapid, sensitive, and specific identification of microorganisms. This editorial provides a comprehensive overview of LOC technology, highlighting its principles, advantages, applications, challenges, and future directions.
View Article and Find Full Text PDFEvaluation of the Adhesion Strength of Ultrathin Gold Coatings on Substrates of Soda-Lime Glass and Cyclo-Olefin-Polymer by Cross-Cut and Scratch Tests under the Influence of a Thermal Shock Test for Use in Biosensors.
ACS Omega
January 2025
Institute for Micro Integration (IFM), University of Stuttgart, Allmandring 9B, 70569 Stuttgart, Germany.
The current demand for highly sensitive, optical sensors in biodiagnostics has prompted the development of ultrathin metal coatings on a range of substrates. Given the potential attenuation of the signal from a plasmonic sensor for the detection of fluorescent molecules when an adhesion layer between the substrate and coating is employed, this study examines the impact of various factors on the adhesion strength between gold coatings and substrates comprising glass and cyclo-olefin-polymer (COP). The objective is to identify potential configurations for high adhesion strength, thereby eliminating the need for an adhesion layer in the fabrication of optical sensors with gold coatings for diagnostic applications or to utilize a minimal adhesion layer thickness.
View Article and Find Full Text PDFMitigating dithiothreitol interference to gold/thiol interface in electrochemical detection of cathepsin B activity toward multiplex protease analysis.
Biosens Bioelectron
January 2025
Department of Chemistry, Kansas State University, Manhattan, KS, 66502, USA. Electronic address:
Proteases are overexpressed at various stages of conditions such as cancers and thus can serve as biomarkers for disease diagnosis. Electrochemical techniques to detect the activity of extracellular proteases have gained attraction due to their multiplexing capability. Here we employ an electrochemical approach based on a 3 × 3 gold (Au) microelectrode array (MEA) functionalized with (2-aminoethyl)ferrocene (AEF) tagged specific peptide substrates to monitor cathepsin B (CB) protease activity.
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