Depleting glutathione by xCT inhibition induces iron-dependent ferroptotic cell death, which is suppressed by lipophilic antioxidants. We screened food extracts with xCTKO-MEFs, identifying garlic extracts as particularly potent in inhibiting ferroptosis among the food extracts examined in this study. xCTKO-MEFs can serve as a convenient tool for identifying food extracts that are effective in inhibiting ferroptosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/bbb/zbae090 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women.
Sci Rep
January 2025
Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Cannabidiol (CBD), a specialized metabolite (phytocannabinoid) abundant in Cannabis sativa, is attracting increasing attention for its alleged health-promoting properties. The present study aimed to investigate the pharmacokinetics of CBD and its primary metabolite, 7-hydroxy-cannabidiol (7-OH-CBD), following a single oral dose of a CBD-rich Cannabis sativa extract, equivalent to 70 mg CBD, in healthy male (n=5) and female (n=6) participants. Using a randomized crossover design, the study evaluated the impact of a standardized high-fat meal compared to fasting on the oral bioavailability of CBD.
View Article and Find Full Text PDFFish active packaging with ZnO/Fe-MMT nanoparticles.
Sci Rep
January 2025
Nanotechnology Department, Faculty of Science, Urmia University, Urmia, Iran.
Today, active packaging has become essential to increase food safety and decrease food spoilage. In this study, the aim was to delay spoilage and increase the shelf life of rainbow fish fillets with a new hybrid nanocomposite active packaging. Packaging was fabricated with Ethylene vinyl acetate and active compounds such as rosemary extract, zinc oxide nanoparticles, and modified iron (Fe-MMT).
View Article and Find Full Text PDFBioactive Compounds and Fatty Acid Composition of Oils Obtained by Different Extraction Methods from Caper (Capparis ovata Desf.) Seeds.
J Oleo Sci
January 2025
Department of Plant Sciences, North Dakota State University.
In this study, the total phenol, total flavonoid content, antioxidant capacity, phenolic component and fatty acid profiles of caper seed oils extracted by solvent extraction, sonication extraction and cold press methods were revealed. Total phenol amounts of caper seed oils extracted by cold press, sonication and solvent systems were recorded as 0.10, 0.
View Article and Find Full Text PDFAqueous extract of Atractylodes macrocephala Koidz. improves dexamethasone-induced skeletal muscle atrophy in mice by enhancing mitochondrial biological function.
Exp Gerontol
January 2025
School of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Purpose: The study aims to investigate the therapeutic effects of the aqueous extract of Atractylodes macrocephala Koidz. (AEA) on dexamethasone (Dex) -induced sarcopenia in mice and to explore its possible mechanisms of action.
Methods: This study utilized bioinformatics analysis to explore the primary pathogenic mechanisms of age-related sarcopenia and Dex-induced muscle atrophy.
Optimized pure cellulose from rice straw using low alkali concentration for sustainable nanocellulose and nanohydrogel production with enhanced dye reduction.
Int J Biol Macromol
January 2025
Department of Food Technology and Nutrition, Lovely Professional University, Phagwara 144411, Punjab, India. Electronic address:
Conversion of rice straw into nanocellulose offers a sustainable approach to agricultural waste management, yielding an industrially important product with potential applications. This work focuses on effectively extracting pure cellulose from both widely used Basmati and Parmal rice straw (BRS and PRS) using less alkali concentrations (3-5 % NaOH). The process was optimized via Box Behnken design at 90-150 °C temperatures for 90-150 min, which resulted in 88.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!