AI Article Synopsis
- Post-stroke depression (PSD) is a common psychological condition following a stroke, with significant impacts on patient health, and research into its causes and treatments is still developing.
- Patients with PSD often show gastrointestinal symptoms, leading to increased interest in how gut microbiota may affect the condition and its management.
- The review highlights that gut microbiota can influence PSD by regulating neurotransmitters, impacting the endocrine system, affecting energy metabolism, and modulating immune responses.
Article Abstract
Post-stroke depression (PSD) is a psychological disease that can occur following a stroke and is associated with serious consequences. Research on the pathogenesis and treatment of PSD is still in the infancy stage. Patients with PSD often exhibit gastrointestinal symptoms; therefore the role of gut microbiota in the pathophysiology and potential treatment effects of PSD has become a hot topic of research. In this review, describe the research on the pathogenesis and therapy of PSD. We also describe how the gut microbiota influences neurotransmitters, the endocrine system, energy metabolism, and the immune system. It was proposed that the gut microbiota is involved in the pathogenesis and treatment of PSD through the regulation of neurotransmitter levels, vagal signaling, hypothalamic-pituitary-adrenal axis activation and inhibition, hormone secretion and release, in addition to immunity and inflammation.
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| http://dx.doi.org/10.1016/j.brainresbull.2024.111022 | DOI Listing |
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