AI Article Synopsis
- The study aimed to assess the effectiveness of serological surveys in differentiating between communities with and without Leishmania transmission to support the elimination of visceral leishmaniasis in the Indian subcontinent.!
- Blood samples from seven villages in India were tested using three serological methods: rK39 RDT, direct agglutination test (DAT), and rK39 ELISA.!
- Results indicated that the rK39 ELISA was the most effective method for distinguishing between endemic and non-endemic areas, showing clear differences in seroprevalence, particularly among children under 10 years old.!
Article Abstract
Objectives: Monitoring of Leishmania transmission is considered a strategic priority for sustaining elimination of visceral leishmaniasis as a public health problem in the Indian subcontinent. The objective of this study was to evaluate whether serological surveys can distinguish between communities with and without Leishmania transmission, and to assess which serological marker performs best.
Methods: Seven villages were selected from Bihar and Uttar Pradesh state, India, and categorized as either currently endemic (CE), previously endemic (PE) or nonendemic (NE). Blood samples were analyzed with the rK39 RDT, direct agglutination test (DAT), and rK39 ELISA.
Results: Contrary to the rK39 RDT and DAT, the rK39 ELISA showed a significant difference between all three categories of endemicity, with a seroprevalence of 5.21% in CE villages, 1.55% in PE villages, and 0.13% in NE villages. Even when only looking at the seroprevalence among children aged <10 years, the rK39 ELISA was still able to differentiate between villages with and without ongoing transmission.
Conclusion: Our findings suggest the rK39 ELISA to be the most promising marker for monitoring of Leishmania transmission. Further validation is required, and practical, context-adapted recommendations need to be formulated in order to guide policymakers toward meaningful and sustainable surveillance strategies in the post-elimination phase.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442319 | PMC |
| http://dx.doi.org/10.1016/j.ijid.2024.107153 | DOI Listing |
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