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Small cell lung cancer unveiled: Exploring the untapped resource of circulating tumor cells-derived organoids.
Crit Rev Oncol Hematol
January 2025
Institute of Biomedicine of Seville (IBiS), HUVR, CSIC, University of Seville, Seville 41013, Spain; Spanish Center for Biomedical Research Network in Oncology (CIBERONC), Madrid 28029, Spain. Electronic address:
Small cell lung cancer (SCLC) remains a challenge in oncology due to its aggressive behavior and dismal prognosis. Despite advances in treatments, novel strategies are urgently needed. Enter liquid biopsy-a game-changer in SCLC management.
View Article and Find Full Text PDFNanoscale Structure and Interfacial Electrochemical Reactivity of Moiré-Engineered Atomic Layers.
Acc Chem Res
January 2025
Department of Chemistry, University of California, Berkeley, California 94720, United States.
ConspectusThe electronic properties of atomically thin van der Waals (vdW) materials can be precisely manipulated by vertically stacking them with a controlled offset (for example, a rotational offset─i.e., twist─between the layers, or a small difference in lattice constant) to generate moiré superlattices.
View Article and Find Full Text PDFMitigating Glycation and Oxidative Stress in Aesthetic Medicine: Hyaluronic Acid and Trehalose Synergy for Anti-AGEs Action in Skin Aging Treatment.
Clin Cosmet Investig Dermatol
November 2024
Dermoklinika Medical Center, Lodz, Poland.
This comprehensive review explores the pivotal roles of glycation and oxidative stress in the aging process of the skin, emphasizing their targeted therapeutic applications in aesthetic and regenerative medicine, as well as anti-aging interventions. Glycation, a biochemical process involving the non-enzymatic attachment of sugars to proteins, lipids, or nucleic acids, culminates in the formation of Advanced Glycation End products (AGEs). These AGEs are significant contributors to aging and various chronic ailments, triggering oxidative stress and inflammatory pathways, thereby manifesting as wrinkles, diminished skin elasticity, and other age-related dermal alterations.
View Article and Find Full Text PDFThe Potential of mRNA Vaccines to Fight Against Viruses.
Viral Immunol
October 2024
Department of Clinical Laboratory, National Clinical Research Center for Child Health Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Vaccines have always been a critical tool in preventing infectious diseases. However, the development of traditional vaccines often takes a long time and may struggle to address the challenge of rapidly mutating viruses. The emergence of mRNA technology has brought revolutionary changes to vaccine development, particularly in rapidly responding to the threat of emerging viruses.
View Article and Find Full Text PDFUltrasensitive Terahertz Label-Free Metasensors Enabled by Quasi-Bound States in the Continuum.
Research (Wash D C)
September 2024
Department of Physics and International Laser Center, Lomonosov Moscow State University, Leninskie Gory 1, Moscow 19991, Russia.
Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors, holding promise for early diagnostics and the detection of low-concentration analytes. Here, we developed a chip-based ultrasensitive terahertz (THz) metasensor, leveraging a quasi-bound state in the continuum (BIC) to address the challenges associated with intricate operations in trace biochemical detection. The metasensor design features an open-ring resonator metasurface, which supports magnetic dipole -BIC combining functionalized gold nanoparticles (AuNPs) bound with a specific antibody.
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