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Preoperative Gabapentin for Pain Control: A Randomized, Placebo-controlled Clinical Trial in Patients Undergoing Inguinal Hernioplasty. | LitMetric

Preoperative Gabapentin for Pain Control: A Randomized, Placebo-controlled Clinical Trial in Patients Undergoing Inguinal Hernioplasty.

J Perianesth Nurs

Programa de Pós Graduação em Ciências da Saúde, Faculdade de Saúde Santa Casa BH, Belo Horizonte, Minas Gerais, Brazil.

Published: December 2024

AI Article Synopsis

  • * In a double-blind, randomized, placebo-controlled trial involving 77 patients, those who received gabapentin reported significantly lower pain scores and reduced morphine usage compared to the placebo group.
  • * The findings suggest that gabapentin effectively lowers postoperative pain and decreases the need for opioids without increasing adverse events, indicating its potential as a beneficial pain management option in this surgical context.

Article Abstract

Purpose: The perioperative use of gabapentin has been suggested to reduce postoperative pain and opioid consumption. However, there is a variation in clinical practice, the type of surgery and the administration time seem to be distinct between the available studies. We assess whether gabapentin administered before surgery reduces postoperative pain in patients who have undergone inguinal hernioplasty.

Design: This is a double-blind, randomized, and placebo-controlled trial.

Methods: Seventy-seven patients scheduled for inguinal hernioplasty were randomized in two groups to receive gabapentin (900 mg) or placebo in the perioperative period. The primary outcome was analgesia measured by visual analog scale up to 30 days after surgery. The secondary outcomes such as morphine consumption, nausea, headache, and sedation have been also described.

Findings: Patients who received gabapentin had lower postoperative pain scores compared to the control group, P < .001. The postoperative morphine use was significantly lower in the gabapentin (5.3%) versus placebo group (74.4%), P < .001. No significant difference between groups was observed for the occurrence of adverse events.

Conclusions: The perioperative administration of gabapentin was effective in reducing postoperative pain and had an important effect in decreasing morphine use. Together, our data reveal a long-lasting opioid-sparing effect of gabapentin in patients who underwent inguinal hernioplasty.

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Source
http://dx.doi.org/10.1016/j.jopan.2024.01.018DOI Listing

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