AI Article Synopsis
- - Osteoarthritis (OA) leads to changes in knee shape, but age alone isn't the sole cause, making it essential to study how knee shape evolves naturally with aging.
- - The study involved 96 participants who underwent CT scans to create 3D models of their knees and used statistical shape modeling to analyze the relationship between knee shape and age.
- - Results showed that specific changes in femoral and tibial bone shapes are linked to aging, with larger bone volumes and certain morphological changes occurring as a normal part of aging, not necessarily due to OA.
Article Abstract
Osteoarthritis (OA) causes bony shape changes within the knee. Furthermore, the risk of developing OA increases with age. However, age alone does not cause OA. It is therefore important to understand the healthy age-related trajectories of knee shape before attributing these changes to OA. The aim of this study was to determine the association between bony knee shape and age using statistical-shape modelling (SSM). 96 participants received a CT scan of their knee. Three-dimensional models were created using manual segmentation. Separate SSM's for the distal femur and proximal tibia were created. Linear regression models were used to assess the association between age and femoral and tibial shape. Fourteen modes of the femoral and tibial SSM's captured 68% and 73% shape variation, respectively. Only femoral mode 3 and tibial mode 7 were associated with age. Increasing age was related to larger femoral bone volume and deepening of the femoral trochlear groove. Furthermore, increased age was associated with medial tibial plateau expansion. Aspects of bony femoral and tibial shape were significantly associated with aging, including femoral and tibial bone size, femoral trochlear groove, and medial tibial plateau area. Changes in knee morphology occur as a normal process of aging without osteoarthritis development. This may be a response to mechanical loading over time. Further research investigating the effect of these changes on loading in the knee may provide valuable information for knee health in older age.
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| http://dx.doi.org/10.1002/jor.25923 | DOI Listing |
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