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promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway. | LitMetric

promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway.

Cytotechnology

Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), No. 1017, Dongmen North Road, Luohu District, Shenzhen, 518020 Guangdong China.

Published: August 2024

Unlabelled: A previous study indicated that patients with androgenic alopecia (AGA) have significantly reduced levels of . This study investigates whether promotes hair-follicle recovery and its possible mechanism. Hair alteration and cutaneous histopathological changes induced by testosterone propionate were observed by H&E and bromodeoxyuridinc (BrdU) stain to evaluate the therapeutic effect of in C57BL/6 J mice. The cellular viability was analyzed in -transfected human hair-follicle stem cells (HFSCs) in vitro. The signaling pathways and pro-proliferative factors were investigated by transcriptomic gene sequencing and qRT-PCR. transfection successfully recovered hair growth and hair-follicle cells in AGA mice. In a series of HFSC studies in vitro, transfection greatly promoted cellular proliferation and decreased cellular apoptosis. Transcriptome gene sequencing suggested that the phosphatidylinositol 3-kinase (PI3K)-Akt pathway was upregulated by . The qRT-PCR results showed that fibroblast growth factor (FGF)-2 was 14-times upregulated after transfection. Hair-follicle recovery activity of may involve the upregulation of and PI3K-Akt to promote follicle stem cell survival. These data not only provide a theoretical basis for AGA development but also reveal a novel therapeutic method for AGA patients.

Supplementary Information: The online version contains supplementary material available at 10.1007/s10616-024-00624-3.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196536PMC
http://dx.doi.org/10.1007/s10616-024-00624-3DOI Listing

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