AI Article Synopsis
- Our understanding of type 2 diabetes (T2D) has changed significantly, challenging long-held beliefs and providing new insights into its onset and progression.
- The review discusses historical misconceptions about T2D, emphasizing new evidence related to beta cell function and the defects that affect glucose regulation.
- It advocates for a shift in management practices, focusing on complication-centric prescribing to enhance treatment strategies from prediabetes to advanced T2D.
Article Abstract
Our understanding of type 2 diabetes (T2D) has evolved dramatically. Advances have upended entrenched dogmas pertaining to the onset and progression of T2D, beliefs that have prevailed from the early era of diabetes research-and continue to populate our medical textbooks and continuing medical education materials. This review article highlights key insights that lend new governing principles for gold standard management of T2D. From the historical context upon which old beliefs arose to new findings, this article outlines evidence and perspectives on beta cell function, the underlying defects in glucoregulation, the remediable nature of T2D, and, the rationale supporting the shift to complication-centric prescribing. Practical approaches translate this rectified understanding of T2D into strategies that fill gaps in current management practices of prediabetes through late type 2 diabetes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199379 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1394805 | DOI Listing |
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