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| http://dx.doi.org/10.1016/j.fmre.2024.03.011 | DOI Listing |
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Revisiting the concept of giant viruses.
Microbes Infect
December 2024
Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais (UFMG). Belo Horizonte, Minas Gerais, 31270-901, Brazil. Electronic address:
Giant viruses have fascinated the scientific community due to their immense particles and extensive genomes. A significant surge of interest in the field has been observed over the past 20 years following the discovery of mimiviruses, the first amoeba-infecting viruses described. However, with the discovery of new amoeba viruses and those from other protists, the concept of "giant viruses" has become increasingly controversial in the scientific literature.
View Article and Find Full Text PDFFrom 'publish or perish' to 'publish with purpose': perspectives from young adults with lived and living experience on transforming academic publishing in patient-oriented research.
Res Involv Engagem
December 2024
HEARTS Study Team, Mental Health Accessibility and Policy Solutions Lab, Mississauga, Ontario, Canada.
Background: This commentary article critically assesses the inclusion and recognition of young adults with lived and living experiences (YALLE) in academic publishing. Stemming from our involvement in a health research study, this analysis interrogates the disparity between the stated importance of YALLE contributions in health research and their actual recognition, specifically in academic publications, which serve as the principal "currency" in research. This tokenism limits the potential for their unique insights to substantially enrich the discourse and dissemination of knowledge.
View Article and Find Full Text PDFA Commentary on Mitochondrial Dysfunction and Compromised DNA Repair in Neurodegeneration: The Emerging Role of FUS in ALS.
Neurosci Insights
December 2024
Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA.
Mitochondrial dysfunction plays a pivotal role in the progression of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's, and Parkinson's disease. Recent discoveries have highlighted the involvement of DNA damage and repair processes, particularly mitochondrial DNA (mtDNA) damage, in these conditions. This commentary reflects on our recent findings, demonstrating the RNA/DNA binding protein fused in sarcoma (FUS)'s crucial role in maintaining mtDNA integrity through interactions with mitochondrial DNA ligase IIIα (mtLig3).
View Article and Find Full Text PDFA new frontier in drug discovery for skin cancer through electronic medical records.
Br J Dermatol
December 2024
Frazer Institute, The University of Queensland, Dermatology Research Centre, Experimental Dermatology Group, Brisbane, Australia.
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