Aims: Carnosinase (CN1) polymorphisms have been linked to diabetic kidney disease (DKD), as CN1 degrades dipeptides which scavenge oxidative metabolites and prevent the formation of advanced glycation end-products. In this work, we studied the association between serum CN1, the systemic redox status and long-term renal outcome in type 1 diabetes.
Methods: Serum CN1 was measured in a prospective type 1 diabetes cohort ( = 218) with a 16-year follow-up. A total of 218 patients treated at the Diabetes Outpatient Clinic of the Weezenlanden Hospital (nowadays Isala Hospital, Zwolle, The Netherlands) were included in this analysis. We assessed whether serum CN1 was associated with renal function and development of DKD as well as other diabetic complications.
Results: At baseline, age, systemic redox status and N-terminal pro brain-natriuretic peptide (NT-proBNP) were associated with serum CN1 concentration ( < 0.05). During follow-up, CN1 concentration in the middle tertile was associated with less incident microalbuminuria (odds ratio = 0.194, 95% C.I.: 0.049-0.772, = 0.02) after adjustment for age, systemic redox status, NT-proBNP and sex.
Discussion: Serum CN1 could predict incident microalbuminuria and may be used as a novel parameter to identify patients at risk for DKD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196470 | PMC |
| http://dx.doi.org/10.1007/s40200-024-01422-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine.
Cureus
October 2024
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Article Synopsis
- - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
- - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
- - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
NODESAFE Nomogram: A Novel Score System to Predict Lymph Node Involvement at the Time of Nephrectomy or Nodal Recurrence in Nonmetastatic Renal Cell Carcinoma.
Clin Genitourin Cancer
December 2024
Department of Urology, UC San Diego Health System, San Diego, CA.
Article Synopsis
- - The study aimed to create a preoperative tool called NODESAFE to predict nodal involvement (NI) in patients with localized renal cell carcinoma (RCC) before surgery, addressing the ongoing debate about the need for lymphadenectomy.
- - Researchers conducted a multicenter analysis of 3,308 RCC patients who had primary surgical resections, excluding those with clinical metastasis, using a stepwise logistic regression model to identify significant predictive factors for NI, achieving an AUC of 0.89 in validation.
- - The final NODESAFE model included factors like hypertension, tumor size, and CRP levels, demonstrating high sensitivity (83.9%) and specificity (86.1%), which could enhance clinical decision-making
Assessing carnosinase 1 activity for diagnosing congenital disorders of glycosylation.
Mol Genet Metab
October 2024
Heidelberg University, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, 69120 Heidelberg, Germany. Electronic address:
Diagnosing Congenital Disorders of Glycosylation (CDG) is challenging due to clinical heterogeneity and the limited sensitivity of the classic serum transferrin isoelectric focusing (IEF) or capillary zone electrophoresis test. This study investigates the potential of using the glycoprotein carnosinase 1 (CN1) activity as a diagnostic marker for CDG patients. CN1 activity was measured photometrically in serum from 81 genetically confirmed CDG patients and healthy individuals.
View Article and Find Full Text PDFRecognition patterns of acute kidney injury in hospitalized patients.
Clin Kidney J
August 2024
Department of Internal Medicine, University of Genova, Genova, Italy.
Background: Acute kidney injury (AKI) during hospitalization is associated with increased complications and mortality. Despite efforts to standardize AKI management, its recognition in clinical practice is limited.
Methods: To assess and characterize different patterns of AKI diagnosis, we collected clinical data, serum creatinine (sCr) levels, comorbidities and outcomes from adult patients using the Hospital Discharge Form (HDF).
Serum carnosinase 1, an early indicator for incident microalbuminuria in type 1 diabetes.
J Diabetes Metab Disord
June 2024
Department of Internal Medicine, University Medical Centre Groningen and University of Groningen, NL-9713 GZ Groningen, the Netherlands.
Aims: Carnosinase (CN1) polymorphisms have been linked to diabetic kidney disease (DKD), as CN1 degrades dipeptides which scavenge oxidative metabolites and prevent the formation of advanced glycation end-products. In this work, we studied the association between serum CN1, the systemic redox status and long-term renal outcome in type 1 diabetes.
Methods: Serum CN1 was measured in a prospective type 1 diabetes cohort ( = 218) with a 16-year follow-up.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!