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Safety of tenofovir alafenamide in people with HIV who experienced proximal renal tubulopathy on tenofovir disoproxil. | LitMetric

AI Article Synopsis

  • * None of the participants experienced a recurrence of PRT or significant changes in kidney function or related biomarkers during the study.
  • * The findings indicate that TAF is a safe and effective treatment choice for those at risk of developing PRT.

Article Abstract

Twenty-eight individuals who experienced proximal renal tubulopathy (PRT, Fanconi syndrome) while receiving tenofovir disoproxil initiated tenofovir alafenamide (TAF) and were followed for 5 years. None developed recurrent PRT or experienced significant changes in estimated glomerular filtration rate (by creatinine or cystatin-C), albuminuria, proteinuria, retinol-binding proteinuria, fractional excretion of phosphate, alkaline phosphatase, or bone mineral density at the lumbar spine. These data suggest that TAF is a well tolerated treatment option for individuals vulnerable to developing PRT.

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Source
http://dx.doi.org/10.1097/QAD.0000000000003916DOI Listing

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