The direct 1,6-nucleophilic difluoromethylation, trifluoromethylation, and difluoroalkylation of -quinone methides (-QMs) with MeSiRf (Rf = CFH, CF, CFCF, CFCOOEt, and CFSPh) under mild conditions are described. Although MeSiCFH shows lower reactivity than MeSiCF, it can react with -QMs promoted by CsF/18-Crown-6 to give structurally diverse difluoromethyl products in good yields. The products can then be further converted into fluoroalkylated -quinone methides and -fluoroalkylated diarylmethanes.
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| http://dx.doi.org/10.3390/molecules29122905 | DOI Listing |
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