AI Article Synopsis
- Solid organ transplant recipients (SOTRs) face a heightened risk of nocardiosis, a serious opportunistic infection, with a study showing only 0.2% (13 out of 6179) of cases diagnosed over 10 years.
- Most patients were male (76.9%), primarily kidney transplant recipients (62%), with infections typically diagnosed around 8.8 months post-transplant.
- The one-year mortality rate after diagnosis was 46%, while low recurrence rates suggest that trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis might be effective in reducing the incidence of this infection.
Article Abstract
Solid organ transplant recipients (SOTRs) are at an increased risk of nocardiosis, a rare but life-threatening opportunistic infection. Universal PCP prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMX) is used at our center, which is active in vitro against most species of the genus and may have a role in preventing early infections. This is a single-center retrospective cohort study of nocardiosis in adult SOTRs at a large transplant center between January 2012 and June 2022, with comprehensive review of literature. Out of 6179 consecutive cases, 13 (0.2%) were diagnosed with nocardiosis. The patients were predominantly male (76.9%) and kidney transplant recipients (62%). Infection was diagnosed at median of 8.8 months (range, 3.7-98) after transplant. Patients were followed for a median of 457 days (range 8-3367). Overall mortality within one year after diagnosis was 46% (6/13), of which 17% (1/6) of deaths was attributable to infection. No recurrence was reported. infections were noted in a small proportion of our SOTRs and carried significant morbidity and mortality. TMP-SMX prophylaxis may be protective in some cases given low incidence of cases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205360 | PMC |
| http://dx.doi.org/10.3390/microorganisms12061156 | DOI Listing |
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