AI Article Synopsis
- Upper urinary tract urolithiasis in cats is primarily caused by calcium oxalate stones, with disturbances in gut and urinary microbiota potentially playing a role in their formation.
- The study examined nine cats with kidney stones and nine healthy cats, finding that those with stones had a less diverse gut microbiota and that antibiotic treatment reduced diversity in both groups.
- The research suggests that specific intestinal bacteria may help degrade oxalate, and their absence could lead to stone formation, indicating that modifying microbiota could be a way to prevent kidney stones in cats.
Article Abstract
Upper urinary tract urolithiasis is an emerging disease in cats, with 98% of kidney stones composed of calcium oxalate. In humans, disturbances in the intestinal and urinary microbiota are suspected to contribute to the formation of calcium oxalate stones. We hypothesized that similar mechanisms may be at play in cats. This study examines the intestinal and urinary microbiota of nine cats with kidney stones compared to nine healthy cats before, during, and after treatment with the antibiotic cefovecin, a cephalosporin. Initially, cats with kidney stones displayed a less diverse intestinal microbiota. Antibiotic treatment reduced microbiota diversity in both groups. The absence of specific intestinal bacteria could lead to a loss of the functions these bacteria perform, such as oxalate degradation, which may contribute to the formation of calcium oxalate stones. This study confirms the presence of a distinct urobiome in cats with kidney stones, characterized by greater richness and diversity compared to healthy cats. These findings highlight the potential of microbiota modulation as a strategy to prevent renal lithiasis in cats.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205531 | PMC |
| http://dx.doi.org/10.3390/microorganisms12061098 | DOI Listing |
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