Transcranial direct current stimulation (tDCS) is emerging as a promising non-invasive intervention for tinnitus by aiming to modulate abnormal brain activity. This study investigated the efficacy of dual-session tDCS for the relief of perception, distress, and loudness in patients with severe chronic subjective tinnitus and assessed the duration of tinnitus suppression effects compared to single-session and control groups over a 2-month follow-up. In a prospective, randomized, single-blind, placebo-controlled trial, 30 participants with severe chronic subjective tinnitus underwent bifrontal tDCS. The control group (n = 9), single-session group (n = 10), and dual-session group (n = 11) received 2 mA stimulation for 20 min per session, twice a week for one month. The treatment response was monitored weekly using the Visual Analogue Scale (VAS), with additional assessments using the Tinnitus Handicap Inventory (THI) and Beck Depression Inventory (BDI) at the fourth and eighth weeks. The single- and dual-session groups showed statistically significant improvements in VAS, THI, and BDI scores compared to the control group. THI and BDI scores showed a significant difference between the single- and dual-session groups. The dual-session group demonstrated a more sustained tinnitus suppression effect than the single-session group. tDCS has been validated as an effective intervention for the suppression of tinnitus, with the dual-session protocol showing longer-term benefits. These findings support the potential of tDCS as a treatment for tinnitus, particularly in dual-session applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205021 | PMC |
| http://dx.doi.org/10.3390/jpm14060577 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of objective methods for analyzing ipsilateral motor evoked potentials in stroke survivors with chronic upper extremity motor impairment.
J Neural Eng
January 2025
Department of Physical Medicine and Rehabilitation, MetroHealth Medical Center, 4229 Pearl Road, Suite N4-13, Cleveland, Ohio, 44109-1998, UNITED STATES.
Ipsilateral motor evoked potentials (iMEPs) are believed to represent cortically evoked excitability of uncrossed brainstem-mediated pathways. In the event of extensive injury to (crossed) corticospinal pathways, which can occur following a stroke, uncrossed ipsilateral pathways may serve as an alternate resource to support the recovery of the paretic limb. However, iMEPs, even in neurally intact people, can be small, infrequent, and noisy, so discerning them in stroke survivors is very challenging.
View Article and Find Full Text PDFEnhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue.
Brain
December 2024
Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Chronic pain and fatigue in musculoskeletal disease contribute significantly to disability, and recent studies suggest an association with reduced motivation and excessive fear avoidance. In this behavioural neuroimaging study, we aimed to identify the specific behavioral and neural changes associated with musculoskeletal pain and fatigue during reward and loss decision-making. Twenty-nine participants with chronic inflammatory arthritis and 28 healthy controls performed an instrumental learning task (4-armed bandit) during 3T brain fMRI.
View Article and Find Full Text PDFThe associations between sleep disturbances and allostatic load, and the role of sex, beta amyloid, and burnout history in a memory clinic sample: the Co‐STAR study.
Alzheimers Dement
December 2024
Ageing Epidemiology Reseach Unit (AGE), School of Public Health, Imperial College London, London, UK
Background: Several studies have investigated the link between sleep disturbances and allostatic load (AL), but the results are varied, and less is known about the associations in clinical samples. The goal of this study is to assess the associations between sleep disturbances and AL among memory clinic participants, and to examine differences according to sex, beta‐amyloid status and history of burnout status.
Method: The study was based on 146 memory clinic participants diagnosed with either Mild Cognitive Impairment (MCI) or Subjective Cognitive Impairment (SCI) in the Cortisol and Stress in Alzheimer’s Disease Study (Co‐STAR) (Sweden).
Differences between white matter hyperintensities lesion load across allostatic load risk in cognitive complaint subjects.
Alzheimers Dement
December 2024
Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile
Background: Chronic exposure to stress, quantified by allostatic load (AL), has been postulated as a cause of structural brain changes in the context of dementia. White matter hyperintensities (WMH), detected in MRI FLAIR, are a common brain abnormality representing small vessel disease or degenerative changes in the brain. Here, we studied differences in tract‐specific WMH volume across three risk levels of AL in Chilean subjects with cognitive complaint, to explore links between chronic stress exposure and prodromal steps of dementia.
View Article and Find Full Text PDFDifferent functional structures of the brainstem according to dementia subtypes.
Alzheimers Dement
December 2024
Ajou University School of Medicine, Korea, Suwon, Korea, Republic of (South)
Background: The extent of neurofibrillary changes, one of the pathological hallmarks of AD, correlates with the severity of AD in dementia. The brainstem is known to be the site of neurofibrillary changes in the early stages of Alzhimer’s disease. The neurotransmitter system in the brainstem processes information from subcortical and cortical circuits affect to various cognitive and behavioral responses in the cerebral cortex.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!