AI Article Synopsis
- A deficiency in essential fatty acids (EFAs) and changes in their metabolism may significantly contribute to the development and severity of sepsis, influencing mortality rates.
- The ineffectiveness of treatments like corticosteroids and certain monoclonal antibodies in sepsis can be linked to these altered EFA metabolic pathways.
- Restoring normal EFA metabolism could lead to new therapeutic strategies for preventing and managing sepsis and other serious conditions by balancing inflammatory responses.
Article Abstract
I propose that a deficiency of essential fatty acids (EFAs) and an alteration in their (EFAs) metabolism could be a major factor in the pathogenesis of sepsis and sepsis-related mortality. The failure of corticosteroids, anti-TNF-α, and anti-interleukin-6 monoclonal antibodies can be attributed to this altered EFA metabolism in sepsis. Vitamin C; folic acid; and vitamin B1, B6, and B12 serve as co-factors necessary for the activity of desaturase enzymes that are the rate-limiting steps in the metabolism of EFAs. The altered metabolism of EFAs results in an imbalance in the production and activities of pro- and anti-inflammatory eicosanoids and cytokines resulting in both hyperimmune and hypoimmune responses seen in sepsis. This implies that restoring the metabolism of EFAs to normal may form a newer therapeutic approach both in the prevention and management of sepsis and other critical illnesses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205989 | PMC |
| http://dx.doi.org/10.3390/medicina60060934 | DOI Listing |
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Article Synopsis
- A deficiency in essential fatty acids (EFAs) and changes in their metabolism may significantly contribute to the development and severity of sepsis, influencing mortality rates.
- The ineffectiveness of treatments like corticosteroids and certain monoclonal antibodies in sepsis can be linked to these altered EFA metabolic pathways.
- Restoring normal EFA metabolism could lead to new therapeutic strategies for preventing and managing sepsis and other serious conditions by balancing inflammatory responses.
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