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The Antioxidant PAPLAL Protects against Allergic Contact Dermatitis in Experimental Models. | LitMetric

The Antioxidant PAPLAL Protects against Allergic Contact Dermatitis in Experimental Models.

Antioxidants (Basel)

Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.

Published: June 2024

PAPLAL, a mixture of platinum (nPt) and palladium (nPd) nanoparticles, is widely used as a topical agent because of its strong antioxidant activity. Allergic contact dermatitis (ACD) is one of the most common occupational skin diseases worldwide. However, the role of oxidative stress in ACD remains unclear. In the present study, we investigated the protective effects of topical PAPLAL treatment on 2,4-dinitrofluorobenzene (DNFB)-induced ACD. DNFB treatment increased 8-isoprostane content; upregulated , , and , pro-oxidant genes; and downregulated , an antioxidant gene, indicating oxidative damage in the ear skin. PAPLAL therapy significantly reduced ear thickness associated with the downregulation of inflammatory cytokine-related genes. PAPLAL also significantly increased the expression of the stress-response-related genes and as well as their target genes, but failed to alter the expression of redox-related genes. Furthermore, loss worsened ACD pathologies in the ear. These results strongly suggest that PAPLAL protects against ACD through its antioxidant activity and activation of the AHR and NRF2 axes. The antioxidant PAPLAL can be used as a novel topical therapy for ACD that targets oxidative stress.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200398PMC
http://dx.doi.org/10.3390/antiox13060748DOI Listing

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