AI Article Synopsis
- Retrograde axonal neurodegeneration affects the visual pathway in conditions like multiple sclerosis (MS), as well as in other types of lesions, showing impacts even without previous optic neuritis.
- Optical coherence tomography (OCT) is a noninvasive method used to observe changes in the macula and optic nerve due to this degeneration.
- The paper reviews how OCT can identify hemimacular atrophy in MS patients, advocating for separate evaluations of different macular areas alongside standard visual assessments.
Article Abstract
Retrograde axonal neurodegeneration along the visual pathway-either direct or trans-synaptic-has already been demonstrated in multiple sclerosis (MS), as well as in compressive, vascular, or posttraumatic lesions of the visual pathway. Optical coherence tomography (OCT) can noninvasively track macular and optic nerve changes occurring as a result of this phenomenon. Our paper aimed to review the existing literature regarding hemimacular atrophic changes in the ganglion cell layer identified using OCT examination in MS patients without prior history of optic neuritis. Homonymous hemimacular atrophy has been described in post-chiasmal MS lesions, even in patients with normal visual field results. Temporal and nasal macular OCT evaluation should be performed separately in all MS patients, in addition to an optic nerve OCT evaluation and a visual field exam.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202963 | PMC |
| http://dx.doi.org/10.3390/diagnostics14121255 | DOI Listing |
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