Exogenous Application of dsRNA in Plant Protection: Efficiency, Safety Concerns and Risk Assessment.

Int J Mol Sci

Julius Kühn Institute (JKI), Federal Research Centre for Cultivated Plant, Institute for Biosafety in Plant Biotechnology, D-06484 Quedlinburg, Germany.

Published: June 2024

AI Article Synopsis

  • The use of double-stranded RNA (dsRNA) is emerging as a sustainable alternative to traditional pesticides for plant protection, highlighting its safety and efficiency.
  • The review stresses the importance of careful consideration of safety, including potential off-target effects and challenges in formulation.
  • It also discusses the regulatory requirements across different regions, advocating for tailored guidelines while emphasizing collaboration among scientists, regulators, and industry to ensure responsible use of dsRNA in agriculture.

Article Abstract

The use of double-stranded RNA (dsRNA) for plant protection shows great potential as a sustainable alternative to traditional pesticides. This review summarizes the current state of knowledge on using exogenous dsRNA in plant protection and includes the latest findings on the safety and efficiency of this strategy. The review also emphasizes the need for a cautious and comprehensive approach, considering safety considerations such as off-target effects and formulation challenges. The regulatory landscape in different regions is also discussed, underscoring the need for specific guidelines tailored to dsRNA-based pesticides. The review provides a crucial resource for researchers, regulators, and industry stakeholders, promoting a balanced approach incorporating innovation with thorough safety assessments. The continuous dialog emphasized in this review is essential for shaping the future of dsRNA-based plant protection. As the field advances, collaboration among scientists, regulators, and industry partners will play a vital role in establishing guidelines and ensuring the responsible, effective, and sustainable use of dsRNA in agriculture.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204322PMC
http://dx.doi.org/10.3390/ijms25126530DOI Listing

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