AI Article Synopsis
- Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, with unpredictable disability progression, and dopamine is linked to both its pathogenesis and treatment.
- The study focused on Caucasian patients with relapsing-remitting MS, assessing disease progression through the Multiple Sclerosis Severity Score while exploring the impact of specific single nucleotide polymorphisms (SNPs) in dopaminergic receptor genes.
- Results indicated that patients with particular genotypes (G/G for rs6280 and rs1800828 SNPs) had significantly higher severity scores, suggesting that these genetic markers could help understand MS progression and inform personalized treatment strategies.
Article Abstract
Background: Multiple sclerosis (MS) is a common chronic autoimmune disease of the central nervous system. In MS, disability progresses unpredictably. Dopamine (DA) is a modulator of immune functions, and compelling evidence supports its involvement in both pathogenesis and treatment of MS. Although single nucleotide polymorphisms (SNPs) in dopaminergic receptor (DR) genes have been extensively studied, their role in MS progression remains unexplored. Therefore, the aim of this explorative study is to investigate the potential association between functional SNPs in DR genes and MS progression.
Methods: Caucasian patients with relapsing-remitting (RR) MS were enrolled, and disease progression assessed by the Multiple Sclerosis Severity Score (MSSS).
Results: Out of the 59 RRMS patients enrolled, those with the G/G genotype for rs6280 and rs1800828 SNPs in DRD3 showed significantly higher MSSSs compared to those with ancestral and heterozygous genotypes.
Conclusions: If confirmed in a larger prospective study, the reported findings could contribute to a better understanding of MS pathophysiological mechanisms, opening the way for the identification of marker(s) for assessing MS progression as well as novel therapeutic strategies. A personalized approach to MS management has the potential to improve the overall well-being of MS patients and alleviate the burden on their caregivers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11203028 | PMC |
| http://dx.doi.org/10.3390/genes15060736 | DOI Listing |
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