AI Article Synopsis
- - The study identifies APPL2, an adaptor protein, as a key factor that decreases in major organs of aged mice, linking it to physiological changes associated with ageing.
- - Reducing APPL2 levels leads to premature ageing in human umbilical vein endothelial cells and also causes ageing-related symptoms in a model organism, including slower movement and shortened lifespan.
- - The research highlights the role of autophagy, showing that enhancing it can mitigate age-related issues, while its decline due to low APPL2 levels contributes to the overall ageing process.
Article Abstract
Ageing has been identified as an independent risk factor for various diseases; however, the physiological basis and molecular changes related to ageing are still largely unknown. Here, we show that the level of APPL2, an adaptor protein, is significantly reduced in the major organs of aged mice. Knocking down APPL2 causes premature ageing of human umbilical vein endothelial cells (HUVECs). We find that a lack of , the homologue of mammalian APPL2, leads to premature ageing, slow movements, lipid deposition, decreased resistance to stresses, and shortened lifespan in (), which are associated with decreased autophagy. Activating autophagy by rapamycin or inhibition of suppresses the age-related alternations, impaired motility, and shortened lifespan of , which are reversed by knocking down autophagy-related genes. Our work provides evidence that APPL2 and its homologue decrease with age and reveals that a lack of bridges autophagy decline and ageing in .
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202736 | PMC |
| http://dx.doi.org/10.3390/genes15060659 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Beneficial death: A substantial element of evolution?
Biogerontology
January 2025
Clinic for Heart Surgery (UMH), Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
If a shortened lifespan is evolutionarily advantageous, it becomes more likely that nature will strive to change it accordingly, affecting how we understand aging. Premature mortality because of aging would seem detrimental to the individual, but under what circumstances can it be of value? Based on a relative incremental increase in fitness, simulations were performed to reveal the benefit of death. This modification allows for continuous evolution in the model and establishes an optimal lifespan even under challenging conditions.
View Article and Find Full Text PDFBrain Age Modeling and Cognitive Outcomes in Young Adults With and Without Sickle Cell Anemia.
JAMA Netw Open
January 2025
Department of Neurology, Washington University in St Louis School of Medicine, St Louis, Missouri.
Importance: Both sickle cell anemia (SCA) and socioeconomic status have been associated with altered brain structure and cognitive disability, yet precise mechanisms underlying these associations are unclear.
Objective: To determine whether brains of individuals with and without SCA appear older than chronological age and if brain age modeling using brain age gap (BAG) can estimate cognitive outcomes and mediate the association of socioeconomic status and disease with these outcomes.
Design, Setting, And Participants: In this cross-sectional study of 230 adults with and without SCA, individuals underwent brain magnetic resonance imaging (MRI) and cognitive assessment.
An 18-year comprehensive safety study on microfocused ultrasound and monopolar radiofrequency combined with cosmetic injectables in 1,040 patients.
Arch Dermatol Res
January 2025
Department of Dermatology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea.
Microfocused ultrasound (MFU) and (MRF) are non-invasive modalities widely used for skin rejuvenation and are often combined with injectables, including neuromodulators and soft tissue fillers. However, large-scale, long-term safety data on such combination therapies are lacking. To address this gap, we conducted a retrospective chart review at two private practice dermatology clinics in South Korea from June 2005 to December 2023.
View Article and Find Full Text PDFThe anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway.
Geroscience
January 2025
Department of Neuropathology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico City, Mexico.
D-β-hydroxybutyrate, BHB, has been previously proposed as an anti-senescent agent in vitro and in vivo in several tissues including vascular smooth muscle. Moreover, BHB derivatives as ketone esters alleviate heart failure. Here, we provide evidence of the potential therapeutic effect of BHB on Hutchinson-Gilford progeria syndrome (HGPS), a rare condition characterized by premature aging and heart failure, caused by the presence of progerin, the aberrant protein derived from LMNA/C gene c.
View Article and Find Full Text PDFImpact of orthognathic surgery on the cheek area using the Barcelona line.
Int J Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Barcelona, Spain; Maxillofacial Institute, Teknon Medical Center, Barcelona, Spain.
A facial appearance of premature aging due to poor bone support of the soft tissues is frequently found in patients with midface hypoplasia. This study was performed to evaluate the changes in the soft tissues of the cheek area in patients subjected to bimaxillary orthognathic surgery. The cheek line angle and length of 27 consecutive patients who underwent bimaxillary surgery, were measured on cone beam computed tomography scans obtained before surgery and at 1 and 12 months after surgery using 3D software.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!