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Combination of Neovestitol and Vestitol Modifies the Profile of Periodontitis-Related Subgingival Multispecies Biofilm. | LitMetric

AI Article Synopsis

  • * Treatment with CNV at the highest concentration (1600 μg/mL) significantly reduced more bacterial species compared to amoxicillin (25 vs. 13 species) and showed a superior effect in decreasing the metabolic activity of the biofilm.
  • * The findings suggest that CNV could be a promising alternative for managing dental biofilms and reducing their harmful effects, outperforming traditional antibiotic treatment.

Article Abstract

The aim of this study was to evaluate the effect of the combination of neovestitol-vestitol (CNV) compounds obtained from Brazilian red propolis on the microbiological profile of a mature multispecies subgingival biofilm. The biofilm with 32 bacterial species associated with periodontitis was formed for seven days using a Calgary device. Treatment with CNV (1600, 800, 400, and 200 μg/mL), amoxicillin (54 μg/mL), and vehicle control was performed for 24 h on the last day of biofilm formation. Biofilm metabolic activity and DNA-DNA hybridization (checkerboard) assays were performed. The groups treated with CNV 1600 and amoxicillin reduced 25 and 13 species, respectively, compared to the control vehicle treatment ( ≤ 0.05); both reduced , while only CNV reduced . When the data from the two treatments (CNV and AMOXI) were compared, a statistically significant difference was observed in 13 species, particularly members of Socransky's orange complex. Our results showed that CNV at 1600 μg/mL showed the best results regarding the metabolic activity of mature biofilms and obtained a reduction in species associated with the disease, such as , showing a better reduction than amoxicillin. Therefore, CNV seems to be a promising alternative to eradicate biofilms and reduce their pathogenicity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200960PMC
http://dx.doi.org/10.3390/biomedicines12061189DOI Listing

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