AI Article Synopsis
- The study investigates the spread and evolution of carbapenemase-producing ST182 strains, which are increasingly linked to hospital infections worldwide.
- ST182 was found in patients across five continents from 2011 to 2021, and genetic analysis revealed diversity among these strains, with many carrying resistance and virulence genes.
- The research highlights ST182 as a concerning multidrug-resistant lineage that warrants careful monitoring due to its global presence and potential for further outbreaks.
Article Abstract
Background: , and related subspecies remain the most clinically relevant among the complex (ECC). Carbapenemase-producing ECC strains are increasingly identified in hospital-acquired infections and usually belong to four main multilocus sequence types (MLST STs) named ST114, ST93, ST90 and ST78. Instead, ST182 has been sporadically reported among strains, and recently, outbreaks of -producing ST182 clonal strains have emerged. Herein, we aimed to investigate the presence of ST182 and explore its evolution and modes of acquisition.
Methods: A phylogenetic analysis of 646 MLST STs identified among 4685 whole-genome sequencing (WGS) assemblies deposited in public repositories was performed, as well as an in silico comparative and phylogenomic analyses for 55 WGS assemblies of ST182. -harboring contigs were also compared to published plasmid sequences.
Results: ST182 strains were recovered from patients on five continents during 2011-2021. They were divided into three major genomic clusters, comprising a separate clonal complex with six other STs. In 30 out of 55 ST182 WGS assemblies, -harboring structures were identified that were similar to the plasmids predominant in Gram-negative bacteria, harboring resistance genes to multiple antibiotic classes and virulence genes. No associations between the genomic clusters and the country/continent of isolation or the presence and the plasmid types of the -harboring contigs were observed.
Conclusions: Our findings show that ST182 strains have been identified in the past decade worldwide; 54.5% of them carried diverse genetic structures, suggesting recent acquisition of the alleles. Thus, -harboring ST182 is an emerging multidrug-resistant and virulent lineage in ECC strains that requires close monitoring.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200890 | PMC |
| http://dx.doi.org/10.3390/antibiotics13060535 | DOI Listing |
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