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Synaptic architecture of leg and wing premotor control networks in Drosophila. | LitMetric

AI Article Synopsis

  • Animal movement is directed by motor neurons that connect the central nervous system to muscles, with complex premotor networks coordinating these movements for various behaviors.
  • Researchers analyzed the wiring of premotor circuits in Drosophila flies to understand how motor networks control leg and wing movements.
  • They discovered that leg motor modules have a hierarchical structure based on the size of motor neurons, while wing circuits are more flexible in their connectivity, highlighting differences in motor control for distinct body parts.

Article Abstract

Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles. MN activity is coordinated by complex premotor networks that facilitate the contribution of individual muscles to many different behaviours. Here we use connectomics to analyse the wiring logic of premotor circuits controlling the Drosophila leg and wing. We find that both premotor networks cluster into modules that link MNs innervating muscles with related functions. Within most leg motor modules, the synaptic weights of each premotor neuron are proportional to the size of their target MNs, establishing a circuit basis for hierarchical MN recruitment. By contrast, wing premotor networks lack proportional synaptic connectivity, which may enable more flexible recruitment of wing steering muscles. Through comparison of the architecture of distinct motor control systems within the same animal, we identify common principles of premotor network organization and specializations that reflect the unique biomechanical constraints and evolutionary origins of leg and wing motor control.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11356479PMC
http://dx.doi.org/10.1038/s41586-024-07600-zDOI Listing

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