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Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior. | LitMetric

AI Article Synopsis

  • The claustrum is linked to attention and sleep, suggesting it plays a role in managing how we respond to stimuli.
  • Researchers recorded activity in the claustrum of male mice while they slept and participated in an attentional task called 'ENGAGE.'
  • Findings showed that increased activity in an area connected to the claustrum, known as the anterior cingulate cortex (ACCp), led to less responsiveness during sleep and more impulsivity during the task, supporting their role in regulating engagement and behavior.

Article Abstract

The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness to stimuli, which spans the axis of engagement. To test this hypothesis, we recorded claustrum population dynamics from male mice during both sleep and an attentional task ('ENGAGE'). Heightened activity in claustrum neurons projecting to the anterior cingulate cortex (ACCp) corresponded to reduced sensory responsiveness during sleep. Similarly, in the ENGAGE task, heightened ACCp activity correlated with disengagement and behavioral lapses, while low ACCp activity correlated with hyper-engagement and impulsive errors. Chemogenetic elevation of ACCp activity reduced both awakenings during sleep and impulsive errors in the ENGAGE task. Furthermore, mice employing an exploration strategy in the task showed a stronger correlation between ACCp activity and performance compared to mice employing an exploitation strategy which reduced task complexity. Our results implicate ACCp claustrum neurons in restricting engagement during sleep and goal-directed behavior.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208603PMC
http://dx.doi.org/10.1038/s41467-024-48829-6DOI Listing

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