The global increase in pharmaceutical consumption, driven by factors such as aging populations and chronic diseases, has raised concerns regarding the environmental impact of pharmaceutical contaminants. Europe, and more specifically Catalonia (Spain), exhibits high pharmaceutical consumption rates, potentially exacerbating environmental contamination. Pharmaceuticals enter rivers through various pathways, persisting after wastewater treatment plants and posing risks to aquatic organisms and human health. Llobregat and Besòs Rivers in Catalonia, crucial water sources, demonstrate detectable pharmaceutical levels, necessitating comprehensive analysis. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) proves effective in detecting pharmaceutical residues, facilitating their risk assessment. This paper reviews the occurrence, fate, and risks associated with 78 pharmaceuticals and metabolite in Llobregat and Besòs Rivers, using LC-MS/MS for analysis. Understanding pharmaceutical impacts on Catalonian River ecosystems is essential for developing mitigation strategies.
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http://dx.doi.org/10.1007/s11356-024-33967-7 | DOI Listing |
Front Chem
December 2024
African Society for Bioinformatics and Computational Biology, Cape Town, South Africa.
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December 2024
M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
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View Article and Find Full Text PDFPharmaceutics
December 2024
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University, 18 Kremlyovskaya St., 420008 Kazan, Russia.
The combination of macroporous cryogels with synthetic peptide factors represents a promising but poorly explored strategy for the development of extracellular matrix (ECM)-mimicking scaffolds for peripheral nerve (PN) repair. In this study, IKVAV peptide was functionalized with terminal lysine residues to allow its in situ cross-linking with gelatin macromer, resulting in the formation of IKVAV-containing proteinaceous cryogels. The controllable inclusion and distribution of the peptide molecules within the scaffold was verified using a fluorescently labelled peptide counterpart.
View Article and Find Full Text PDFPolymers (Basel)
December 2024
Department of Engineering, Pegaso Telematic University, 80143 Naples, Italy.
Lactic acid (LA) is a versatile, optically active compound with applications across the food, cosmetics, pharmaceutical, and chemical industries, largely driven by its role in producing biodegradable polylactic acid (PLA). Due to its abundance, lignocellulosic biomass is a promising and sustainable resource for LA production, although media derived from these matrices are often rich in xylose and contain growth inhibitors. This study investigates LA production using a xylose-rich medium derived from DC stalks treated through steam explosion and enzymatic hydrolysis.
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December 2024
Institute of Nutrition and Food Technology, University of Chile, El Líbano 5524, Macul, Santiago 7830490, Chile.
Walnut milk residues (WMR) were investigated for the first time through their phenolic characterization including soluble (free, esterified, and etherified) phenolics and those released from their insoluble-bound form (insoluble-bound phenolic hydrolysates, IBPHs) and their antioxidant properties. Free phenolics were recovered and alkaline or acid hydrolysis were used to recover the remaining phenolic fractions. Total phenolic compounds (TPCs) and their antioxidant activity were analyzed by Folin-Ciocalteu, FRAP, and ORAC methods, respectively.
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