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Exploring Psychedelics Pharmacology: A Scoping Review Charting the Course of Psilocybin Pharmacokinetics.
Clin Neuropharmacol
December 2024
Hospital del Mar Research Institute, Barcelona, Spain.
Objectives: This scoping review aimed to synthesize the existing data about psilocybin pharmacokinetics to learn what has been described regarding body disposition and safety when psilocybin was used in controlled research settings.
Methods: We performed a scoping literature review following the framework proposed by the JBI manual for evidence synthesis. Controlled clinical trials reporting pharmacokinetic data of psilocybin were considered appropriate for inclusion.
Modifiable Health Behaviours in Children with HCM: Lessons from the Heart Health Survey.
Pediatr Cardiol
January 2025
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Obesity factors into hypertrophic cardiomyopathy (HCM)-related risk as a disease modifying environmental factor. Behaviours such as diet and sleep are seldom reported upon in children with HCM. It was our aim to report on these factors in this population.
View Article and Find Full Text PDFHigh takeoff of the right coronary artery by echocardiography: normal variant or something more?
Cardiol Young
January 2025
Congenital Heart Center, Division of Pediatric Cardiology, Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Purpose: High takeoff of the right coronary artery suspected by echocardiography is widely considered a normal variant. However, in our experience, some patients initially thought to have a high takeoff of the coronary artery were later found to have an anomalous coronary origin with high-risk features. The aim of this study was to test the hypothesis that high takeoff of the right coronary artery suspected by echocardiography may indicate the presence of an anomalous coronary artery lesion with an intramural course requiring further investigation.
View Article and Find Full Text PDFPrognostic Implications of Occult Nodal Metastases in Patients with Clinically N0 Primary Parotid Gland Cancer.
Medicina (Kaunas)
November 2024
Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
The role of occult nodal metastases in patients with parotid gland cancers remains unclear; such metastases are histologically diverse and exhibit unpredictable clinical courses. Here, we evaluated the prognostic utilities of such metastases, including metastases in the intraparenchymal lymph nodes (PARs). We retrospectively reviewed the medical charts of patients who underwent surgery to treat clinically N0 primary parotid gland cancers from 2000 to 2022.
View Article and Find Full Text PDFA Case Series of Concomitant Falls and COVID-19 Infection Among Older Adults.
Kans J Med
September 2024
Department of Trauma Services, University of Kansas School of Medicine-Wichita, Wichita, KS.
Article Synopsis
- The study focused on elderly patients (65+) with fall-related injuries who were also infected with COVID-19, analyzing their hospital outcomes.
- A total of 807 patients were reviewed, where 16% were tested for COVID-19, resulting in a 17% positivity rate among those tested, showcasing common comorbidities like hypertension and diabetes.
- The findings highlighted significant complications such as respiratory failure and a 19% in-hospital mortality rate, suggesting that COVID-19 poses a severe risk for older adults with fall injuries.
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