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Myelin ensheathment and drug responses of oligodendrocytes are modulated by stiffness of artificial axons.
PLoS One
January 2025
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
Myelination is a key biological process wherein glial cells such as oligodendrocytes wrap myelin around neuronal axons, forming an insulative sheath that accelerates signal propagation down the axon. A major obstacle to understanding myelination is the challenge of visualizing and reproducibly quantifying this inherently three-dimensional process in vitro. To this end, we previously developed artificial axons (AAs), a biocompatible platform consisting of 3D-printed hydrogel-based axon mimics designed to more closely recapitulate the micrometer-scale diameter and sub-kilopascal mechanical stiffness of biological axons.
View Article and Find Full Text PDFBioprinted optoelectronically active cardiac tissues.
Sci Adv
January 2025
Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Electrical stimulation of existing three-dimensional bioprinted tissues to alter tissue activities is typically associated with wired delivery, invasive electrode placement, and potential cell damage, minimizing its efficacy in cardiac modulation. Here, we report an optoelectronically active scaffold based on printed gelatin methacryloyl embedded with micro-solar cells, seeded with cardiomyocytes to form light-stimulable tissues. This enables untethered, noninvasive, and damage-free optoelectronic stimulation-induced modulation of cardiac beating behaviors without needing wires or genetic modifications to the tissue solely with light.
View Article and Find Full Text PDFMarginal Gap Distance and Dynamic Fatigue Performance of Esthetic Crowns for Primary Teeth.
Int J Paediatr Dent
January 2025
Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Background: The growing demand for esthetic restorative materials highlights the need to evaluate their marginal accuracy and fracture resistance to ensure optimal clinical outcomes for primary molars.
Aim: The aim was to assess the vertical marginal gap distance and fracture resistance of esthetic restorative materials after cyclic loading.
Design: Forty extracted primary molars were randomly divided into four groups: Group I, stainless steel veneered crowns with tooth-colored material; Group II, prefabricated monolithic zirconia crowns; Group III, yttria-partially stabilized zirconia computer-aided design/computer-aided manufacturing (CAD/CAM) crowns; and Group IV, hybrid ceramic CAD/CAM crowns.
Next-Generation Dental Materials: Exploring Bacterial Biofilm Formation on 3D-Printable Resin-Based Composites.
J Funct Biomater
January 2025
Dental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil.
This study evaluated the microbial growth profile of subgingival multispecies biofilm on 3D-printable resin-based composites (PRBCs). A 96-well cell plate cultivated a 39-species biofilm associated with periodontitis over 7 days. Cylindrical specimens with 12 mm high and 3 mm diameters were prepared by the PRBC group (Cosmos Temp-Yller; Prizma 3D Bio Crown; Prizma 3D Bio Prov) and an acrylic resin as control.
View Article and Find Full Text PDFElectrochemical Biosensors 3D Printed by Fused Deposition Modeling: Actualities, Trends, and Challenges.
Biosensors (Basel)
January 2025
Graduate Program in Chemistry, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.
The technology of 3D printing, particularly fused deposition modeling (FDM) 3D printing, has revolutionized the development of electrochemical biosensors, offering a versatile and cost-effective approach for clinical applications. This review explores the integration of FDM in fabricating biosensing platforms tailored for clinical diagnostics, emphasizing its role in detecting various biomarkers and viral pathogens. Advances in 3D printing materials, especially the emergence of bespoke conductive filaments, have allowed the production of highly customizable and efficient biosensors.
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