Tinea incognita (TI) can mimic other dermatoses, presenting a diagnostic challenge for dermatologists. In some uncertain cases, it is crucial to accurately identify the causative agent using internal transcribed spacer (ITS) sequencing. The global issue of drug-resistant dermatophytosis is increasing, with Trichophyton (T.) indotineae being the main cause. This study presents four cases of TI (diagnosed as eczema) by terbinafine-resistant T. indotineae strains and reviews the current global TI epidemiology based on geographical continent and related conditions. Furthermore, squalene epoxidase (SQLE)-associated resistance mechanisms are evaluated. Lesions caused by terbinafine-resistant T. indotineae strains do not respond to allylamine antifungals, thus allowing the infection to spread. Among T. indotineae isolates, the SQLE F397L substitution is the most prevalent mutation contributing to azole resistance. F397L and L393F replacements in SQLE were detected in all isolates that exhibited high-level resistance. L393S was seen in isolates with low-resistant strains. Interestingly, and for the first time, an L393F amino acid substitution in the SQLE gene product was detected in the Iranian clinical T. indotineae strain. Also, a genomics-based update on terbinafine resistance that focuses on T. indotineae is discussed in this study.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/ddg.15440 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Terbinafine-resistant T. indotineae due to F397L/L393S or F397L/L393F mutation among corticoid-related tinea incognita patients.
J Dtsch Dermatol Ges
July 2024
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Tinea incognita (TI) can mimic other dermatoses, presenting a diagnostic challenge for dermatologists. In some uncertain cases, it is crucial to accurately identify the causative agent using internal transcribed spacer (ITS) sequencing. The global issue of drug-resistant dermatophytosis is increasing, with Trichophyton (T.
View Article and Find Full Text PDFUpdates on Tinea Incognita: Literature review.
Curr Med Mycol
June 2023
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- * A review of literature was conducted using databases like PubMed and Scopus, focusing on studies from 2006 to February 2023, to analyze the various clinical manifestations, prevalence, and causative agents of TI across different cases.
- * Results indicated that 50% of TI cases displayed eczema-like lesions, with other patterns such as psoriasis-like and rosacea-like also noted; to ensure accurate diagnosis, dermatologists must take a comprehensive patient history.
A clinical prevalence of dermatophytic mycoses with an assessment of its clinical manifestations in a tertiary care hospital at Salem, South India.
Mycoses
February 2024
Department of Pharmacy Practice, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation, (Deemed to be University), Salem, Tamil Nadu, India.
Article Synopsis
- - Dermatophytosis, a type of fungal skin infection, is increasingly common globally, with a study conducted on 3,068 outpatients revealing a prevalence rate of 13.69% among 420 diagnosed cases.
- - The majority of affected patients were female (50.71%) and the most represented age group was 31-40 years, with atypical presentations like tinea incognita being the most frequently observed manifestation.
- - The study found more new cases (326) compared to previously diagnosed ones (94), highlighting that dermatophytic mycoses are a significant concern within this population.
Majocchi's Granuloma - The Great Mimicker: A Case Report.
Case Rep Dermatol
October 2023
Skin Clinic, Kolding, Denmark.
Article Synopsis
- Fungal infections, often mistaken for conditions like eczema or psoriasis, can be difficult to identify and might be improperly treated with topical corticosteroids, leading to a condition called tinea incognita.
- A 54-year-old man experienced a painful rash in the genitoinguinal area that was initially treated unsuccessfully with various topical antifungals and antibiotics.
- Ultimately diagnosed with Majocchi's granuloma after thorough examination and histopathology, the patient successfully improved with a 16-week course of itraconazole, highlighting the need for awareness of such infections among non-specialist doctors.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!