AI Article Synopsis
- - The N-benzyl piperidine (N-BP) motif is an important structural element in drug discovery, known for its flexibility and ability to interact with target proteins.
- - Medicinal chemists leverage the N-BP motif to enhance drug efficacy and optimize properties related to potency and toxicity, identifying its relevance in existing and emerging therapies.
- - The review highlights the N-BP motif's applications in drug development, including its presence in approved drugs and ongoing clinical trials, while also addressing potential challenges in its use for various therapeutic targets.
Article Abstract
The N-benzyl piperidine (N-BP) structural motif is commonly employed in drug discovery due to its structural flexibility and three-dimensional nature. Medicinal chemists frequently utilize the N-BP motif as a versatile tool to fine-tune both efficacy and physicochemical properties in drug development. It provides crucial cation-π interactions with the target protein and also serves as a platform for optimizing stereochemical aspects of potency and toxicity. This motif is found in numerous approved drugs and clinical/preclinical candidates. This review focuses on the applications of the N-BP motif in drug discovery campaigns, emphasizing its role in imparting medicinally relevant properties. The review also provides an overview of approved drugs, the clinical and preclinical pipeline, and discusses its utility for specific therapeutic targets and indications, along with potential challenges.
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| http://dx.doi.org/10.1002/cmdc.202400384 | DOI Listing |
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