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Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping.
J Diabetes
January 2025
Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing City, Jiangsu Province, China.
Background: Iron is one of the most important elements in brain that may has a direct impact on the stability of central nervous system. The current study devoted to explore the alterations of iron distribution across the whole brain in type 2 diabetes mellitus (T2DM) patients with mild cognitive impairment (MCI).
Methods: The quantitative susceptibility mapping (QSM) technique was used to quantify the intracranial iron content of 74 T2DM patients with MCI and 86 T2DM patients with normal cognition (NC).
Ecotoxicological impact of succinate dehydrogenase inhibitor (SDHI) fungicides on non-targeted organisms: a review.
Ecotoxicology
January 2025
Amity Institute of Environmental Sciences, Amity University, Sector-125, Noida, 201301, Uttar Pradesh, India.
As the global population continues to grow, the use of pesticides to increase food production is projected to escalate. Pesticides are critical in plant protection, offering a powerful defense against fungal diseases such as apple scab, leaf spot, sclerotinia rot, damping off, sheath blight, and root rot, which threaten crops like cereals, corn, cotton, soybean, sugarcane, tuberous vegetables, and ornamentals. Succinate Dehydrogenase Inhibitor (SDHI) fungicides represent a novel class essential for controlling fungal pathogens and bolstering food security.
View Article and Find Full Text PDFPredicting changes in agricultural yields under climate change scenarios and their implications for global food security.
Sci Rep
January 2025
School of BioSciences, Centre of Excellence for Biosecurity Risk Analysis, University of Melbourne, Melbourne, 3010, Australia.
Climate change has direct impacts on current and future agricultural productivity. Statistical meta-analysis models can be used to generate expectations of crop yield responses to climatic factors by pooling data from controlled experiments. However, methodological challenges in performing these meta-analyses, together with combined uncertainty from various sources, make it difficult to validate model results.
View Article and Find Full Text PDFControllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording.
Microsyst Nanoeng
January 2025
National Key Laboratory of Advanced Micro and Nano Manufacture Technology, Shanghai Jiao Tong University, Shanghai, China.
Precise and long-term electroanalysis at the single-cell level is crucial for the accurate diagnosis and monitoring of brain diseases. The reliable protection in areas outside the signal acquisition points at sharp ultramicroelectrode (UME) tips has a significant impact on the sensitivity, fidelity, and stability of intracellular neural signal recording. However, it is difficult for existing UMEs to achieve controllable exposure of the tip functional structure, which affects their ability to resist environmental interference and shield noise, resulting in unsatisfactory signal-to-noise ratio and signal fidelity of intracellular recordings.
View Article and Find Full Text PDFSerum proteomics reveals early biomarkers of Alzheimer's disease: The dual role of APOE-ε4.
Biosci Trends
January 2025
Department of Neurosurgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China.
Alzheimer's disease (AD), the leading cause of dementia, significantly impacts global public health, with cases expected to exceed 150 million by 2050. Late-onset Alzheimer's disease (LOAD), predominantly influenced by the APOE-ε4 allele, exhibits complex pathogenesis involving amyloid-β (Aβ) plaques, neurofibrillary tangles (NFTs), neuroinflammation, and blood-brain barrier (BBB) disruption. Proteomics has emerged as a pivotal technology in uncovering molecular mechanisms and identifying biomarkers for early diagnosis and intervention in AD.
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