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Health-Related Quality of Life in Patients with Friedreich Ataxia Using Mobility Assistive Technologies: Limited Fit of the EQ-5D-3L Mobility Dimension.
Neurol Ther
December 2024
Patient-Reported Outcomes and Health Economics Research, Deutsches Zentrum für Neurodegenerative Erkrankungen/German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Ellernholzstrasse 1-2, 17489, Greifswald, Germany.
Introduction: Friedreich Ataxia (FA) is a multisystem neurodegenerative disease. Affected individuals rely on mobility assistive technologies (MAT) (e.g.
View Article and Find Full Text PDFMapping the future of oxidative RNA damage in neurodegeneration: Rethinking the status quo with new tools.
Proc Natl Acad Sci U S A
November 2024
Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093.
Over two decades ago, increased levels of RNA oxidation were reported in postmortem patients with ALS, Alzheimer's, Parkinson's, and other neurodegenerative diseases. Interestingly, not all cell types and transcripts were equally oxidized. Furthermore, it was shown that RNA oxidation is an early phenomenon, altogether indicating that oxidative RNA damage could be a driver, and not a consequence, of disease.
View Article and Find Full Text PDFWe need to rethink outcomes in Parkinson's disease research.
BMJ
October 2024
Copenhagen Trial Unit, Rigshospitalet, Denmark.
Tipping the Scales: Indiscriminate Use of Interval Scales to Rate Diverse Dysarthric Features.
J Speech Lang Hear Res
October 2024
Department of Communication Sciences and Disorders, The University of Iowa, Iowa City.
Purpose: Error related to incorrect use of rating scales is problematic in the assessment and treatment of dysarthria. The main purpose of this project was to determine scale fit for cardinal speech features of hypokinetic dysarthria. A secondary aim was to determine rater reliability for the two different scales explored.
View Article and Find Full Text PDFUnveiling the Neurodegenerative Alterations through Oral Stem Cells.
J Dent Res
October 2024
Stem Cells and Medical Genetics Units, Tecnologica Research Institute and Marrelli Health, Crotone, Italy.
Parkinson's disease (PD) is a neurodegenerative condition characterized by the progressive and selective loss of dopaminergic (DAergic) neurons in the midbrain. The replacement of neuromelanin (NM)-containing DAergic neurons in the substantia nigra and the enhancement of NM concentration could offer a promising and safe approach to treating PD symptoms. The objective of this study was to investigate and compare the potential of human periapical-cysts mesenchymal stem cells (hPCy-MSCs) and dental pulp stem cells (DPSCs) to differentiate into DAergic NM-producing neurons and to generate functional 3-dimensional (3D) midbrain-like organoids in vitro.
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