Vascular calcification-A hard nut to crack.

Ther Apher Dial

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Published: October 2024

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http://dx.doi.org/10.1111/1744-9987.14179DOI Listing

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Article Synopsis
  • * Researchers analyzed data from 156 patients, measuring aortic calcification index (ACI) via CT scans and examining blood serum for specific cytokines; they found that elevated levels of CTACK and MIG cytokines were significantly associated with higher ACI.
  • * The study's findings indicate that higher levels of CTACK and MIG may reflect the severity of atherosclerotic disease in the aorta, potentially linking them to other cardiovascular health issues.
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Vascular calcification-A hard nut to crack.

Ther Apher Dial

October 2024

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

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Purpose: Environmental pollutant Bisphenol A (BPA) strongly interacts with insulin resistance, which leads to type 2 diabetes mellitus (T2DM). Uncontrolled glucose levels in both blood and urine develops vascular complications in T2DM patients. However, glucose-controlled diabetic patients are also affected by vascular complications due to vascular calcification, and there is a lack of clinically relevant data on BPA levels available in patients with T2DM-associated vascular complications due to vascular calcification.

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Systemic sclerosis skin is a primed microenvironment for soft tissue calcification-a hypothesis.

Rheumatology (Oxford)

June 2021

Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester & Salford Royal NHS Foundation Trust, Manchester, UK.

Calcinosis cutis, defined as sub-epidermal deposition of calcium salts, is a major clinical problem in patients with SSc, affecting 20-40% of patients. A number of recognized factors associated with calcinosis have been identified, including disease duration, digital ischaemia and acro-osteolysis. Yet, to date, the pathogenesis of SSc-related calcinosis remains unknown, and currently there is no effective disease-modifying pharmacotherapy.

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Diabetes and Abdominal Aortic Calcification-a Systematic Review.

Curr Osteoporos Rep

February 2018

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Purpose Of Review: A systematic literature review was performed to evaluate diabetes mellitus (DM) as a risk factor of abdominal aortic calcification (AAC), and address factors that might contribute to the development of AAC in DM patients.

Recent Findings: DM is an independent risk factor of AAC development. Bone metabolism along with lifestyle factors among DM patients makes them more prone to AAC.

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