Trivalent phosphine catalysis is mostly utilized to activate the carbon-carbon multiple bonds to form carbanion intermediate species and is highly sensitive to certain variables. Random manual multi-variables are critical for understanding the batch disabled regeneration of trivalent phosphine chemistry. We need the artificial intelligence-based system which can change the variable based on previously conducted failed experiment. Herein, we report an auto-optimized electro-micro-flow reactor platform for the in-situ reduction of stable P(V) oxide to sensitive P(III) and further utilized the method for Corey-Fuchs reaction.
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