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http://dx.doi.org/10.1111/apt.18129 | DOI Listing |
J Am Coll Cardiol
March 2025
Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address:
Biogerontology
March 2025
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Front Psychiatry
February 2025
Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Spain.
Unlabelled: Autism spectrum disorder (ASD) refers to a group of complex neurodevelopmental disorders and is characterized by impaired reciprocal social interaction and communication, as well as the presence of restricted interests and stereotyped and repetitive behaviors. As a complex neurodevelopmental disorder, the phenotype and severity of autism are extremely heterogeneous, with differences from one patient to another. Chromosome microarray (CMA) and fragile X syndrome analyses has been used as a powerful tool to identify new candidate genes for ASD.
View Article and Find Full Text PDFFront Immunol
March 2025
Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Sterile systemic inflammation may contribute to neuroinflammation and accelerate the progression of neurodegenerative diseases. The double-stranded RNA-dependent protein kinase (PKR) is a key signaling molecule that regulates immune responses by regulating macrophage activation, various inflammatory pathways, and inflammasome formation. This study aims to study the role of PKR in regulating sterile systemic inflammation-triggered neuroinflammation and cognitive dysfunctions.
View Article and Find Full Text PDFFront Immunol
March 2025
DKMS Group, Tübingen, Germany.
Introduction: In hematopoietic stem cell transplantation, optimal results are achieved when donors and patients are matched regarding their human leukocyte antigen (HLA) genes. Population-specific HLA allele and haplotype frequency distributions determine the probabilities to find matched donors in a stem cell donor registry of given size and ethnic composition.
Methods: To evaluate the needs of Indian patients with regard to future donor recruitment, we analyzed a large data set of =130,518 potential stem cell donors registered with DKMS-BMST, a Bangalore-based donor registry with nationwide donor recruitment activities.
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