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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Amsterdam UMC, Amsterdam, Amsterdam, Netherlands.
Background: Amyotrophic lateral sclerosis (ALS) with only motor impairment (ALS-pure motor) and the behavioral variant of frontotemporal dementia (bvFTD) are hypothesized to be the extreme ends of the ALS-bvFTD spectrum. This spectrum also encompasses ALS patients with mild to severe cognitive impairment (ALSci) and/or behavioral impairment (ALSbi), including ALS with concomitant bvFTD. In a previous study, using magnetoencephalography (MEG), in early symptomatic ALS patients we showed resting-state functional connectivity changes in frontal, limbic and subcortical regions that overlap considerably with bvFTD.
View Article and Find Full Text PDFA copula-based multivariate flood frequency analysis under climate change effects.
Sci Rep
January 2025
Department of Civil Engineering, Isfahan University of Technology, Isfahan, Iran.
Floods are among the most severe natural hazards, causing substantial damage and affecting millions of lives. These events are inherently multi-dimensional, requiring analysis across multiple factors. Traditional research often uses a bivariate framework relying on historical data, but climate change is expected to influence flood frequency analysis and flood system design in the future.
View Article and Find Full Text PDFHyperspectral inversion of heavy metal content in farmland soil under conservation tillage of black soils.
Sci Rep
January 2025
College of Jilin Emergency Management, Changchun Institute of Technology, Changchun, 130012, China.
Globally, heavy metal (HM) soil pollution is becoming an increasingly serious concern. Heavy metals in soils pose significant environmental and health risks due to their persistence, toxicity, and potential for bioaccumulation. These metals often originate from anthropogenic activities such as industrial emissions, agricultural practices, and improper waste disposal.
View Article and Find Full Text PDFUse of refractive aids among adults in a general population.
Sci Rep
January 2025
Department of Clinical Medicine, Aarhus University, Aarhus N, DK-8200, Denmark.
Spectacles and contact lenses are important for conducting a normal life in a large part of the general population. The purpose of this study was to estimate the use of these refractive aids in a normal adult population, and to identify characteristics of persons who should be targeted in order to improve uncorrected refraction. In the FORSYN study, 10,350 citizens representative for the adult Danish population were invited for a non-cycloplegic eye examination.
View Article and Find Full Text PDFTargeted plasma metabolomics reveals potential biomarkers of the elderly with mild cognitive impairment in Qingdao rural area.
Front Aging Neurosci
December 2024
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, Shandong, China.
Introduction: Previous research has suggested a link between the onset of Alzheimer's disease (AD) and metabolic disorder; however, the findings have been inconsistent. To date, the majority of metabolomics studies have focused on AD, resulting in a relative paucity of research on early-stage conditions such as mild cognitive impairment (MCI) underexplored. In this study, we employed a comprehensive platform for the early screening of individuals with MCI using high-throughput targeted metabolomics.
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