AI Article Synopsis
- African horse sickness is a deadly viral disease affecting horses, with transmission by biting midges leading to over 90% mortality in susceptible horses; it's primarily found in sub-Saharan Africa but has caused outbreaks in Europe and Asia, creating economic troubles.
- There are existing attenuated vaccines, but concerns about their safety and effectiveness drive the search for better alternatives, such as virus-like particles, which may offer improved safety and efficacy for vaccination.
- The review explores the challenges of producing these vaccines, particularly in resource-limited countries, and highlights the potential of using plants for recombinant protein expression as a more economical production method.
Article Abstract
African horse sickness is a devastating viral disease of equids. It is transmitted by biting midges of the genus with mortalities reaching over 90% in naïve horses. It is endemic to sub-Saharan Africa and is seasonally endemic in many parts of southern Africa. However, outbreaks in Europe and Asia have occurred that caused significant economic issues. There are attenuated vaccines available for control of the virus but concerns regarding the safety and efficacy means that alternatives are sought. One promising alternative is the use of virus-like particles in vaccine preparations, which have the potential to be safer and more efficacious as vaccines against African horse sickness. These particles are best made in a complex, eukaryotic system, but due to technical challenges, this may cause significant economic strain on the developing countries most affected by the disease. Therefore, this review also summarises the success so far, and potential, of recombinant protein expression in plants to reduce the economic strain of production.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206403 | PMC |
| http://dx.doi.org/10.3390/pathogens13060458 | DOI Listing |
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