Four new cyclic pentapeptides, avellanins D-G (-), together with four known compounds (-), were isolated from a mangrove-derived GXIMD 03099 fungus from L. Their structures were elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. Their absolute configurations were determined by X-ray diffraction analysis and Marfey's method. Compounds - were screened for insecticidal and antibacterial activities. Compound showed insecticidal activity against newly hatched larvae of with an LC value of 86.6 µM; compound had weak activity against with an MIC value of 5.85 µM.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204760 | PMC |
| http://dx.doi.org/10.3390/md22060282 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cyclic Ruthenium-Peptide Prodrugs Penetrate the Blood-Brain Barrier and Attack Glioblastoma upon Light Activation in Orthotopic Zebrafish Tumor Models.
ACS Cent Sci
December 2024
Leiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.
The blood-brain barrier (BBB) presents one of the main obstacles to delivering anticancer drugs in glioblastoma. Herein, we investigated the potential of a series of cyclic ruthenium-peptide conjugates as photoactivated therapy candidates for the treatment of this aggressive tumor. The three compounds studied, , , and ([Ru(Phphen) Ac-XRGDX-NH)]Cl with Phphen = 4,7-diphenyl-1,10-phenanthroline and X, X = His or Met), include an integrin-targeted pentapeptide coordinated to a ruthenium warhead via two photoactivated ruthenium-X bonds.
View Article and Find Full Text PDFIn-Depth Structural Analysis of a Stapled Pentapeptide and Its Assembly Into Straight α-Helices.
Small
December 2024
Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, China.
Peptide self-assembly is a complex hierarchical process involving the progressive formation of secondary structures, such as α-helices, β-sheets, and turns, during the early stages. It is precisely these multi-component building blocks that contribute to the complexity of protein assemblies in living organisms. While coiled coils are well-understood in protein folding, determining the structural characteristics governing their lateral packing remains challenging.
View Article and Find Full Text PDFCyclopeptide Avellanins D-O with Antimalarial Activity from the Mariana Trench Anemone-Derived MSC5.
J Nat Prod
December 2024
State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.
Article Synopsis
- * Researchers used advanced techniques including MALDI-TOF MS, NMR, and LC-MS/MS to analyze a fungus (MSC5) from the Mariana Trench, leading to the discovery of 12 new cyclic pentapeptides known as avellanins D-O and one known compound, avellanin C.
- * The structure of these compounds was determined through several analytical methods, and one of them showed strong antimalarial activity with an IC value of 0.19 ± 0.09 μM, highlighting its potential for medicinal use.
Chemical constituents from the culture of SWUF15-40 fungus and the inhibitory activity against cancer cell proliferation and nitric oxide production.
Nat Prod Res
November 2024
Center of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Article Synopsis
- - The study examined the chemical diversity of the SWUF15-40 fungus grown in a yeast-malt extract medium, shifting from the previous PDB medium using the OSMACs strategy, which resulted in discovering numerous bioactive compounds.
- - Detailed analysis using IR, NMR, MS, and XRD techniques led to the identification of two new isopimarane derivatives, three guaiane derivatives, and four known compounds.
- - A cyclic pentapeptide from the fungus showed promising anti-cancer activity against several cell lines and inhibited nitric oxide production, indicating that adjusting growth conditions can enhance the discovery of bioactive compounds in fungi.
A metal-organic nanoframework for efficient colorectal cancer immunotherapy by the cGAS-STING pathway activation and immune checkpoint blockade.
J Nanobiotechnology
September 2024
Key Laboratory of Emergency and Trauma of Ministry of Education, Engineering Research Center for Hainan Biological Sample Resources of Major Diseases, The Hainan Branch of National Clinical Research Center for Cancer, the First Clinical College & the First Affiliated Hospital, Hainan Medical University, Haikou, 570102, China.
Immunotherapy has shown marked progress in promoting systemic anti-colorectal cancer (CRC) clinical effects. For further effectively sensitizing CRC to immunotherapy, we have engineered a pH-sensitive zeolitic imidazolate framework-8 (CS/NPs), capable of efficient cGAS-STING pathway activation and immune checkpoint blockade, by encapsulating the chemotherapeutic mitoxantrone (MTX) and immunomodulator thymus pentapeptide (TP5) and tailoring with tumor-targeting chondroitin sulfate (CS). In this nanoframework, CS endows CS/NPs with specific tumor-targeting activity and reduced systemic toxicity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!