Clavatols exhibit a wide range of biological activities due to their diverse structures. A genome mining strategy identified an cluster from sp. MYA5, derived from the Arctic plant , is responsible for clavatol biosynthesis. Seven clavatols, including one new clavatol derivate named penicophenone F () and six known clavatols (-), were isolated from sp. MYA5 using a transcriptome mining strategy. These structures were elucidated by comprehensive spectroscopic analysis. Antibacterial, aldose reductase inhibition, and siderophore-producing ability assays were conducted on compounds -. Compounds and demonstrated inhibitory effects on the ALR2 enzyme with inhibition rates of 75.3% and 71.6% at a concentration of 10 μM, respectively. Compound exhibited antibacterial activity against and with MIC values of 4.0 μg/mL and 4.0 μg/mL, respectively. Additionally, compounds , , and also showed potential iron-binding ability.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205228 | PMC |
| http://dx.doi.org/10.3390/md22060236 | DOI Listing |
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