Two new polyketide derivatives, penirubenones A and B ( and ), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B ( and ), together with nine known compounds (-) were isolated from the marine-derived fungus BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and C NMR data. We found that exhibited antibacterial activity against , with an MIC value of 3.125 μg/mL, and and showed synergistic antifungal activity against at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204949 | PMC |
| http://dx.doi.org/10.3390/jof10060424 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Retraction: Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis.
RSC Adv
January 2025
Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou 350014 P. R. China +86-591-8366-0063.
[This retracts the article DOI: 10.1039/C8RA09506J.].
View Article and Find Full Text PDFIdentification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations.
Biomolecules
November 2024
Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
NF-κB-inducing kinase (NIK) plays a pivotal role in regulating both the canonical and non-canonical NF-κB signaling pathways, driving the expression of proteins involved in inflammation, immune responses, and cell survival. Overactivation of NIK is linked to various pathological conditions, including chronic inflammation, autoimmune diseases, metabolic disorders, and cancer progression. As such, NIK represents a compelling target for therapeutic intervention in these diseases.
View Article and Find Full Text PDFEnhanced Synthesis, Purification, and Characterization of a Marine Bacterial Consortium-Derived Protease Enzyme With Destaining and Keratinolytic Activity.
Biotechnol Appl Biochem
December 2024
Department of Life Sciences, Hemchandracharya North Gujarat University, Patan, Gujarat, India.
Two marine-derived bacteria, Bacillus paralicheniformis (HR-1) and Bacillus haynesii (HR-5), were isolated from sediments and identified using 16S ribosomal RNA gene amplification and sequencing as well as biochemical analysis. The development of a bacterial consortium (HR-1 & HR-5) from these two bacteria was used to increase the production of the protease enzyme under various conditions, including fermentation media, carbon and nitrogen sources (1% w/v), different pH levels, incubation time, and the obtained enzyme, were detected using SDS-PAGE followed by purification. Bacterial consortium HR-1 & HR-5 exhibited maximum protease production (330.
View Article and Find Full Text PDFGenome mining and biosynthetic pathways of marine-derived fungal bioactive natural products.
Front Microbiol
December 2024
School of Bioengineering, Zunyi Medical University, Zhuhai, China.
Marine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent. This review highlights recent efforts in genome mining and biosynthetic pathways of bioactive natural products from marine fungi, focusing on methods such as bioinformatics analysis, gene knockout, and heterologous expression to identify relevant BGCs and elucidate the biosynthetic pathways and enzyme functions of MFNPs.
View Article and Find Full Text PDFBenzaldehyde and azaphilone derivatives from the marine-derived fungus PSU-AMF89.
Nat Prod Res
December 2024
School of Science, Walailak University, Thasala, Nakhonsithammarat, Thailand.
Two new compounds including one benzaldehyde () and one azaphilone () were isolated from the marine-derived fungus PSU-AMF89 together with nine known compounds (-). Their structures were determined by spectroscopic evidences. The absolute configuration of was established by comparison of the ECD data with those of the previously reported data of compound as well as the biosynthetic consideration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!