AI Article Synopsis
- Chronic obstructive pulmonary disease (COPD) can lead to malnutrition, which may affect patients' health and exacerbate their condition; this study explored how body composition and handgrip strength relate to exacerbation frequencies in COPD patients.
- The research involved analyzing 159 COPD patients, focusing on differences between those who experience frequent versus infrequent exacerbations regarding muscle health and body composition metrics.
- Results indicated that higher extracellular water ratios were linked to increased exacerbation risk, while lower phase angles suggested poorer muscle quality; these factors could help predict exacerbation likelihood in COPD patients.
Article Abstract
Background: Chronic obstructive pulmonary disease (COPD), characterized by high-energy metabolism, often leads to malnutrition and is linked to exacerbations. This study investigates the association of malnutrition-related body composition and handgrip strength changes with exacerbation frequencies in COPD patients.
Methods: We analyzed 77 acute exacerbation COPD (AECOPD) patients and 82 stable COPD patients, categorized as frequent and infrequent exacerbators. Assessments included body composition, handgrip strength, nutritional risk, dyspnea scale, and COPD assessment.
Results: Among AECOPD patients, there were 22 infrequent and 55 frequent exacerbators. Infrequent exacerbators showed better muscle parameters, extracellular water ratio, phase angle, and handgrip strength. Significant differences in intracellular water, total cellular water, protein, and body cell mass were observed between groups. Logistic regression indicated that extracellular water ratio (OR = 1.086) and phase angle (OR = 0.396) were independently associated with exacerbation risk. Thresholds for exacerbation risk were identified as 0.393 for extracellular water ratio and 4.85° for phase angle. In stable COPD, 13 frequent and 69 infrequent exacerbators were compared, showing no significant differences in weight, muscle, and adipose parameters, but significant differences in extracellular water ratio, phase angle, and handgrip strength.
Conclusions: These findings suggest that increased exacerbations in COPD patients correlate with higher extracellular water ratios and lower phase angles.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200775 | PMC |
| http://dx.doi.org/10.3390/arm92030023 | DOI Listing |
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