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http://dx.doi.org/10.3389/fendo.2024.1400583 | DOI Listing |
Cancer Immunol Res
January 2025
Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Novel therapeutic strategies are needed to improve the efficacy of chimeric antigen receptor (CAR) T cells as a treatment of solid tumors. Multiple tumor microenvironmental factors are thought to contribute to resistance to CAR T-cell therapy in solid tumors, and appropriate model systems to identify and examine these factors using clinically relevant biospecimens are limited. In this study, we examined the activity of B7-H3-directed CAR T cells (B7-H3.
View Article and Find Full Text PDFInt J Surg
January 2025
Department of thoracic and cardiovascular surgery, Huashan Hospital, Affiliated with Fudan University, Shanghai, China.
Background: Pulmonary ischemia-reperfusion injury (PIRI) is a major cause of fatality post-lung transplantation. Though some long non-coding RNAs (lncRNAs) have been studied in acute lung injury (ALI), their effects on PIRI remain undefined. The present study aims to explore the underlying mechanism of small nucleolar RNA host gene 16 (SNHG16) in PIRI.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Department of Chemistry, University of North Dakota, Grand Forks, ND, 58202, USA.
Regulation of gene expression in eukaryotic cells is critical for cell survival, proliferation, and cell fate determination. Misregulation of gene expression can have substantial, negative consequences that result in disease or tissue dysfunction that can be targeted for therapeutic intervention. Several strategies to inhibit gene expression at the level of mRNA transcription and translation have been developed, such as anti-sense inhibition and CRISPR-Cas9 gene editing.
View Article and Find Full Text PDFJ Extracell Vesicles
January 2025
State Key Laboratory of Reproductive Medicine and offspring health, Nanjing Medical University, Nanjing, China.
As functional derivatives of mesenchymal stem cells (MSCs), small extracellular vesicles (sEVs) have garnered significant attention and application in regenerative medicine. However, the technical limitations for large-scale isolation of sEVs and their heterogeneous nature have added complexity to their applications. It remains unclear if the heterogeneous sEVs represent different aspects of MSCs functions.
View Article and Find Full Text PDFBackground: Alzheimer's Disease (AD) is neuropathologically characterized by the accumulation of Amyloid-β (Aβ) plaques, neurofibrillary tangles, and neuroinflammation. GPR3 is a G protein-coupled receptor (GPCR) that has been implicated in Aβ pathogenesis via β-arrestin 2 (βarr2)-mediated intracellular signaling. Genetic deletion of Gpr3 reduces the Aβ plaque burden and cognitive decline in AD transgenic mice.
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